羧甲淀粉钠溶液辅助治疗儿童支气管哮喘的临床观察  

Clinical Observation of Carboxymethylstarch Sodium Solution in Auxiliary Treatment of Pediatric Bronchial Asthma

作　　者：彭静君[1] 李文成[1] 李波[1] 林勇[2] PENG Jingjun;LI Wencheng;LI Bo;LIN Yong(Dept. of Pediatrics,Zunyi First People’s Hospital,Guizhou Zunyi 563002,China;Pediatric ICU,Zunyi First People’s Hospital,Guizhou Zunyi 563002,China)

机构地区：[1]遵义市第一人民医院儿科,贵州遵义563002 [2]遵义市第一人民医院儿童重症医学科,贵州遵义563002

出　　处：《中国药房》2017年第17期2413-2415,共3页China Pharmacy

摘　　要：目的:观察羧甲淀粉钠溶液辅助治疗儿童支气管哮喘的临床疗效及安全性。方法:选取我院2015年3月-2016年3月收治的支气管哮喘患儿102例,根据患儿入院先后顺序分为观察组和对照组,各51例。对照组患儿给予吸入用布地奈德混悬液0.5~1 mg雾化吸入,tid+吸入用异丙托溴铵溶液1~2 mL雾化吸入,tid+氨溴特罗口服溶液2.5~15 mL,po,bid;观察组患儿在此基础上给予羧甲淀粉钠溶液7 mL(1~<4岁)、10 mL(4~12岁),po,tid。两组患儿均治疗3个月。观察两组患儿的临床疗效、咳嗽喘息缓解时间、肺部哮鸣音消失时间、住院时间和免疫指标[免疫球蛋白G(IgG)、IgM、IgA]水平,并记录不良反应发生情况。结果:观察组患儿的总有效率(90.2%)明显高于对照组(70.6%),咳嗽喘息缓解时间、肺部哮鸣音消失时间、住院时间明显短于对照组,差异均有统计学意义(P<0.05)。治疗前,两组患儿Ig G、Ig M和Ig A水平比较,差异均无统计学意义(P>0.05);治疗后,观察组患儿上述免疫指标水平较治疗前明显升高,且明显高于对照组,差异均有统计学意义(P<0.05)。两组患儿治疗过程中均未见明显不良反应发生。结论:羧甲淀粉钠溶液辅助治疗儿童支气管哮喘疗效较好,可提高患儿免疫力,且安全性较高。OBJECTIVE:To observe clinical efficacy and safety of Carboxymethylstarch sodium solution in auxiliary treatmentof pediatric bronchial asthma.METHODS:Totally102children with bronchial asthma selected from our hospital during Mar.2015-Mar.2016were divided into observation group and control group according to admission order,with51cases in each group.Control group was given aerosol inhalation of Budesonide suspension for inhalation0.5-1mg,tid+aerosol inhalation of Ipratropiumbromide solution for inhalation1-2mL+Ambroxol hydrochloride and clenbuterol hydrochloride oral solution2.5-15mL,po,bid.Observation group was additionally given Carboxymethylstarch sodium solution7mL(1-<4years old),10mL(4-12yearsold),po,tid.Both groups received treatment for3months.Clinical efficacy,the time of cough and wheezing relief,the time oflung wheezing disappearance,hospitalization time and the levels of immune indexes(IgG,IgM,IgA)were observed in2groups,and the occurrence of ADR was recorded.RESULTS:Total response rate of observation group(90.2%)was significantly higher thanthat of control group(70.6%),and the time of cough and wheezing relief,the time of lung wheezing disappearance and hospitalizationtime of observation group were significantly shorter than those of control group,with statistical significance(P<0.05).Therewas no statistical significance in the levels of IgG,IgM and IgA between2groups before treatment(P>0.05).After treatment,aboveimmune indexes of observation group were significantly higher than before treatment and control group,with statistical significance(P<0.05).No obvious ADR was found in2groups during treatment.CONCLUSIONS:Carboxymethylstarch sodium solution in auxiliarytreatment of pediatric bronchial asthma shows good therapeutic efficacy and improves immunity of children with good safety.

关 键 词：羧甲淀粉钠溶液 儿童 支气管哮喘 免疫力 

分 类 号：R979.5[医药卫生—药品]