黄腐酸有机锡羧酸酯的合成及抗肿瘤活性  

Synthesis and Anti-tumor Activity of Fulvic Acid Organotin Carboxylates

作　　者：陈瑨[1] 霍萃萌[1] 代本才[1] 武传伟 赵永德[1] CHEN Jin;HUO Cuimeng;DAI Bencai;WU Chuanwei;ZHAO Yongde(Institute of Chemistry Co. Ltd.,Henan Academy of Sciences,Zhengzhou 450002,China;Zhengzhou Winsen Electronics Technology Co. Ltd.,Zhengzhou 450001,China)

机构地区：[1]河南省科学院化学研究所有限公司,郑州450002 [2]郑州炜盛电子科技有限公司,郑州450001

出　　处：《河南科学》2017年第6期874-877,共4页Henan Science

基　　金：河南省博士后科研项目资助(2014070)

摘　　要：以黄腐酸和有机锡化合物为原料,合成了8个新的有机锡化合物.通过红外光谱、元素分析、电感耦合等离子体质谱(ICP-MS)对其进行结构表征,并利用MTT法测定了目标化合物的体外抗肿瘤活性.结果显示,目标化合物对人急性骨髓白血病细胞(KG-1a)、大鼠肾上腺髓质嗜铬瘤分化细胞(PC12)和人慢性髓原白血病细胞(K562)均有较好的增殖抑制作用.其中三苯基锡黄腐酸酯(3g)、三环己基锡黄腐酸酯(3h)能较强地抑制被测的三种癌细胞,IC_(50)值在10.79~29.22 mg/L^(-1),抑制效果最好为10.79±0.37 mg/L^(-1);二甲基锡黄腐酸酯(3a)、二辛基锡黄腐酸酯(3f)对PC12细胞的抑制作用也较好,其IC50值分别为34.41±0.61、52.41±1.58 mg/L^(-1).Eight new organotin carboxylates were synthesized from fulvic acid and organotin compounds.Theirstructures were characterized by IR,elemental analysis and ICP-MS,and antitumor activity was determinedby the MTT method.The results showed that they exhibited a good antitumor activity in vitro against KG-1a,PC12andK562.A good antitumor activity of fulvic acid triphenyltin carboxylate(3g)and fulvic acid tricyclohexyltin carboxylate(3h)was exhibited against the three kinds of cancer cells with IC50value of10.79-29.22mg/L-1,and the best was10.79±0.37mg/L-1;the IC50value of fulvic acid dimethyltin carboxylate(3a)and fulvic acid dioctyltin carboxylate(3f)against PC12cells were34.41±0.61,52.41±1.58mg/L-1respectively.

关 键 词：腐植酸 黄腐酸 有机锡羧酸酯 抗肿瘤活性 

分 类 号：O627.4[理学—有机化学]