血浆超敏C反应蛋白和B型脑钠肽检测对老年慢性心力衰竭患者院内恶性室性心律失常发生的临床应用意义分析  

Analysis of clinical significance of plasma high sensitivity C reactive protein and type B brain natriuretic peptide in the diagnosis of malignant ventricular arrhythmias in hospitalized elderly patients with chronic heart failure

作　　者：张相杰[1] ZHANG Xiang-jie(Dongguan City Houjie Hospital, Dongguan 523945, China)

机构地区：[1]东莞市厚街医院,523945

出　　处：《中国现代药物应用》2017年第13期12-14,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析血浆超敏C反应蛋白(hs-CRP)、B型脑钠肽(BNP)检测老年慢性心力衰竭(CHF)患者院内恶性室性心律失常发生的临床应用意义。方法 40例CHF恶性室性心律失常老年患者作为观察组,40例CHF非恶性室性心律失常老年患者作为对照组,测定并对比两组24 h内的hs-CRP与BNP水平。结果观察组的左室射血分数(LVEF)为(38.28±4.37)%,低于对照组的(45.62±5.53)%,差异有统计学意义(P<0.05)。观察组的hs-CRP为(9.22±3.14)mg/L、BNP为(1895.17±310.74)pg/ml,均高于对照组的(3.74±1.15)mg/L、(1352.18±257.83)pg/ml,差异有统计学意义(P<0.05)。经多因素回归分析证实,CHF老年患者院内恶性室性心律失常发生的主要因素为hs-CRP、BNP和LVEF。高浓度hsCRP和BNP发生恶性室性心律失常的患者比例显著高于低水平hs-CRP和BNP患者,差异有统计学意义(P<0.05)。结论 hs-CRP、BNP是判断老年CHF患者发生院内恶性室性心律失常的主要因素,且水平越高,发生率越高。Objective To analyze the clinical significance of plasma high sensitivity C reactive protein(hs-CRP)and type B brain natriuretic peptide(BNP)in the diagnosis of malignant ventricular arrhythmias inhospitalized elderly patients with chronic heart failure(CHF).Methods There were40CHF patients withmalignant ventricular arrhythmias as observation group,and40CHF patients with non-malignant ventriculararrhythmias as control group.Detection and comparison were made on hs-CRP and BNP level in24h in twogroups.Results The observation group had lower left ventricular ejection fraction(LVEF)as(38.28±4.37)%than(45.62±5.53)%in the control group,and the difference had statistical significance(P<0.05).The observationgroup had higher hs-CRP as(9.22±3.14)mg/L and BNP as(1895.17±310.74)pg/ml than(3.74±1.15)mg/L and(1352.18±257.83)pg/ml in the control group,and their difference had statistical significance(P<0.05).Multivariate regression analysis confirmed that the main factors of CHF elderly patients with malignant ventriculararrhythmias were hs-CRP,BNP and LVEF.The proportion of patients with high concentrations of hs-CRP andBNP with malignant ventricular arrhythmias was significantly higher than that of low-grade hs-CRP and BNPpatients,and the difference had statistical significance(P<0.05).Conclusion hs-CRP and BNP are the mainfactors in judging the incidence of malignant ventricular arrhythmia in elderly CHF patients,and the higher thelevel,the higher the incidence.

关 键 词：慢性心力衰竭 超敏C反应蛋白 B型脑钠肽 恶性室性心律失常 老年 

分 类 号：R541.6[医药卫生—心血管疾病]