咪唑斯汀联合雷尼替丁治疗慢性特发性荨麻疹的临床效果及不良反应  

Clinical effect and adverse reactions by mizolastine combined with ranitidine in the treatment of chronic idiopathic urticaria

作　　者：黄文清 HUANG Wen-qing(Department of Dermatology, Xingning City People’s Hospital, Xingning 514500, China)

机构地区：[1]兴宁市人民医院皮肤科,514500

出　　处：《中国现代药物应用》2017年第13期19-21,共3页Chinese Journal of Modern Drug Application

摘　　要：目的研究咪唑斯汀联合雷尼替丁治疗慢性特发性荨麻疹的临床效果及不良反应。方法 88例慢性特发性荨麻疹患者,随机分为单一治疗组和联合治疗组,各44例。单一治疗组采用咪唑斯汀口服治疗,联合治疗组采用咪唑斯汀联合雷尼替丁治疗。比较两组患者治疗效果、不良反应发生率及治疗前后患者细胞因子干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)和瘙痒评分、风团数量的差异。结果联合治疗组患者总有效率为97.73%,显著高于单一治疗组的84.09%,差异具有统计学意义(P<0.05)。治疗后,联合治疗组IL-4、IFN-γ和瘙痒评分、风团数量改善程度均优于对照组,差异具有统计学意义(P<0.05)。联合治疗组患者不良反应发生率为6.82%,单一治疗组为4.55%,比较差异无统计学意义(P>0.05)。结论咪唑斯汀联合雷尼替丁治疗慢性特发性荨麻疹的效果优于单一咪唑斯汀治疗,不良反应少,安全有效,可改善临床症状,减轻炎症水平,对于瘙痒严重患者早期联合其他抗组胺药,可以提高疗效。Objective To research clinical effect and adverse reactions by mizolastine combined withranitidine in the treatment of chronic idiopathic urticaria.Methods A total of88patients with chronic idiopathicurticaria were randomly divided into single treatment group and combined treatment group,with44cases ineach group.The single treatment group received oral administration of mizolastine,and the combined treatmentgroup received mizolastine combined with ranitidine for treatment.Comparison was made on curative effect,incidence of adverse reactions,and differences of interferon-γ(IFN-γ),interleukin-4(IL-4),pruritus score,wheal number before and after treatment between the two groups.Results The combined treatment group hadobviously higher total effective rate as97.73%than84.09%in the single treatment group,and their differencehad statistical significance(P<0.05).After treatment,the combined group had better improvement degree of IL-4,IFN-γ,pruritus score,and wheal number than the control group,and their difference had statistical significance(P<0.05).The combeind treatment group had incidence of adverse reactions as6.82%,which was4.55%in thesingle treatment group,and their difference had no statistical significance(P>0.05).Conclusion Combination of mizolastine and ranitidine in treating chronic idiopathic urticaria shows better effect than single treatmentby mizolastine,and this method shows few adverse reactions,safety and effectiveness.It can improve clinicalsymptoms and relieve inflammation level in patients.Combining with antihistamine drugs,it can improve curativeeffect for patients with severe pruritus.

关 键 词：咪唑斯汀 雷尼替丁 慢性特发性荨麻疹 临床效果 不良反应 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]