黄芩苷对鼻咽癌荷瘤鼠抑瘤作用的实验研究  

An experimental study on the inhibitory effect of baicalin on tumor-bearing mice

作　　者：李静[1] 高雪[1] 李玉凤[1] 李玥[1] 

机构地区：[1]牡丹江医学院红旗医院,黑龙江牡丹江157011

出　　处：《中医临床研究》2017年第13期42-43,共2页Clinical Journal Of Chinese Medicine

摘　　要：目的:观察黄芩苷对鼻咽癌荷瘤小鼠VEGF、IL-2、TNF-α血清中含量的影响,探讨其抑癌机制。方法:40只裸鼠于其鼻咽部接种瘤细胞悬液制造鼻咽癌荷瘤小鼠模型,随机分成5组,即模型对照组、黄芩苷高、中、低剂量组、环磷酰胺(CTX)组,ELISA法检测各组鼠血清中VEGF,IL-2、TNF-α的含量变化。结果:黄芩苷能够抑制鼻咽癌荷瘤小鼠肿瘤的转移和生长,提高免疫器官功能,并减少鼠血清中VEGF的含量,增加IL-2、TNF-α的含量。结论:黄芩苷对鼻咽癌荷瘤小鼠肿瘤的发生发展有抑制作用,其可能是通过调节以上相关因子而发挥作用。Objective: To observe the effect of baicalin on the content of VEGF, IL-2 and TNF-α in tumor-bearing mice withnasopharyngeal darcinoma, and to explore its mechanism of tumor suppressor. Methods: 40 nude mice were randomly divided into fivegroups: the model control group, baicalin high, medium and low dose group, cyclophosphamide group. And the levels of VEGF, IL-2 andTNF-α in the serum in each group were detected by ELISA. Results: Baicalin could inhibit the metastasis and growth of tumor in tumorbearing mice of nasopharyngeal carcinoma, increase the function of immune organ and decrease the content of VEGF, the content of IL-2and TNF-α in mouse serum. Conclusion: Baicalin has an inhibitory effect on the development of tumor in mice bearing nasopharyngealcarcinoma, which may play a role in regulating the above related factors.

关 键 词：黄芩苷 鼻咽癌 血管内皮生长因子 白介素2 肿瘤坏死因子-Α 

分 类 号：R246.81[医药卫生—针灸推拿学]