肺挫伤早期血清TNF.α、IL.1β、IL.10、IL.13和肺超微结构及肺功能的变化  

Changes of serum TNF-α,IL-1β,IL-10,IL-13,lung ultrastructure and respiratory function in the early stage of pulmonary contusion

作　　者：曾礼[1] 王伟[1] 熊新明[1] 方丹青[1] FANG Danqing;ZENG Li;WANG We;XIONG Xinming(Department of Thoracic Surgery,The Second Affiliated Hospital of Guanzhou Medical University,Guanzhou 510260,China)

机构地区：[1]广州医科大学附属第二医院胸外科,广州市510260

出　　处：《实用医学杂志》2017年第12期1933-1936,共4页The Journal of Practical Medicine

基　　金：广东省自然科学基金项目(编号:S2011010002964)

摘　　要：目的:研究肺挫伤早期血清中TNF-α、IL-1β、IL-10、IL-13和肺超微结构及肺功能的变化情况。方法:16只新西兰白兔随机分为肺挫伤组和对照组。建立肺挫伤模型,于挫伤后1、2、3、4 h检测血清TNF-α、IL-1β、IL-10、IL-13含量,同时获取肺功能数据,并观察肺超微病理结构的变化情况。结果:肺挫伤早期TNF-α、IL-1β表达升高,IL-10、IL-13表达持续下降,肺超微结构可见肺泡壁损害,肺泡腔内及间隔间大量炎性渗出,肺泡通气量及PO_2明显下降,P-AO_2持续加大,肺顺应性下降。结论:肺挫伤早期TNF-α、IL-1β表达明显升高,血清IL-10、IL-13表达降低,造成肺组织超微结构进行性破坏,肺功能持续降低。Objective To investigate the changes of serum TNF?α,IL?1β,IL?10,IL?13,lung ultrastructureand respiratory function in the early stage of pulmonary contusion.Method16white rabbits were randomlyassigned to lung contusion group and control group.Pulmonary contusion was established.Serum TNF?α,IL?1β,IL?10and IL?13level at1,2,3and4h after contusion were tested.Respiratory function data was obtained andultrastructure was observed.Results In the early phase after pulmonary contusion,the expression of IL?1βandTNF?αincreased while IL?10and IL?13decreased continuously.Lung ultrastructure changes included alveolar dam?age and massive erythrocyte sedimentation and inflammatory cell exudation in alveolar cavity.Alveolar ventilationand PO2decreased significantly,P?AO2increased continuously and lung compliance reduced.Conclusions In theearly phase after pulmonary contusion,the expression of IL?1βand TNF?αincreases while IL?10and IL?13de?creases,lung ultrastructure is progressively destructed and lung function is severely damaged.

关 键 词：肺挫伤 炎症因子 TNF.α 肺超微结构 肺功能 

分 类 号：R655.3[医药卫生—外科学]