ICSI周期中不同卵母细胞成熟比例与促性腺激素用量的选择对胚胎质量及妊娠结局的影响  

ICSI cycle oocytes maturation ratio and different dosage of gonadotropin choices affecting embryo quality and clinical outcome

作　　者：曾伟荣[1] 杨桂艳[1] 蔡桂丰[1] 阮永铭[1] 熊永崂[1] ZENG Weirong;YANG Guiyan;CAI Guifeng;RUAN Yongming;XIONG Yonglao(The Reproductive Center of Zhuhai Maternal and Child Health Hospital,Zhuhai 519000,China)

机构地区：[1]广东省珠海市妇幼保健院生殖中心,519000

出　　处：《实用医学杂志》2017年第12期1982-1985,共4页The Journal of Practical Medicine

摘　　要：目的:研究卵胞浆内单精子注射(ICSI)治疗过程中不同的卵母细胞成熟比例及促性腺激素用量对胚胎质量及妊娠结局的影响。方法:回顾性分析2015年1-12月就诊行ICSI周期的患者资料,按卵母细胞的成熟比例分成3组。A组为≤50%(低比例组,n=19),B组为50%~80%(中比例组,n=70),C组为>80%(高比例组,n=130),然后再将3组按是否妊娠分为A_0、A_1组,B_0、B_1组,C_0、C_1组,观察不同卵母细胞成熟比例在Gn时间、Gn剂量、正常受精率、卵裂率、优质胚胎率的差异。结果:A、B、C 3组的正常受精率、卵裂率差异无统计学意义(P>0.05);A组的获卵率、优质胚胎率、临床妊娠率与其他2组有明显差异(均P<0.05);妊娠组与未妊娠组中,在同一卵母细胞成熟比例区间,未妊娠组的促性腺激素用量明显高于妊娠组(P<0.05)。结论:在ICSI治疗过程中,促性腺激素的剂量及卵母细胞成熟比例增加不利于卵子的发育潜能及妊娠结局,因此促性腺激素的剂量和卵母成熟比例应控制在一定的范围内,收集并保护好与患者状态相匹配的最优势卵子。Objective To explore ICSI treatment process in the different proportion of oocytes maturationand dosage of gonadotropin affecting embryo quality and clinical outcome.Methods From Jan.to Dec.2015,weretrospectively analyzed the patients from the center line of ICSI cycle,divided them into three groups according tothe maturity of oocytes.The3groups were due to maturity rate of oocytes in50%in group A(n=19),50%<group B≤80%(n=70),over80%in group C(n=130),according to whether pregnancy in A0,A1,B0,B1,C0,C1group.The data was observed in different maturity ratios in Gn days,Gn dose,normal fertilization rate,cleavage rate,high quality embryo rate.Results In the three groups,there were no statistical difference in thenormal fertilization rate,cleavage rate(P>0.05).Group A had the best egg rate,high quality embryo rate,clinicalpregnancy rate than the other two groups(P<0.05).In pregnancy and non?pregnancy groups,the dosage ofgonadotropin in the non?pregnancy group was obviously higher than that in the pregnancy group in oocyte maturationin the same proportion interval(P<0.05).Conclusion In ICSI treatment process,the high dose of gonadotropinand rising rates of oocytes maturation are not conducive to the development potential of the egg and clinicaloutcome,so the dose of gonadotropin and oocyte maturation ratio should be controlled in a certain range to collectand protect the best dominant egg which matches to the state of the patient.

关 键 词：卵胞浆内单精子注射 卵母细胞成熟比例 促性腺激素 临床妊娠率 

分 类 号：R714.8[医药卫生—妇产科学]