白菊木树皮的化学成分及其抗炎活性研究  

Chemical Constituents from Gochnatia decora Barks and Their Anti-inflammatory Activities

作　　者：赵晨星[1] 戴伟锋[1] 李宝才[1] 张金阳[1] 陈强[1] 张敉[1] ZHAO Chen-xing;DAI Wei-feng;LI Bao-cai;ZHANG Jin-yang;CHEN Qiang;ZHANG Mi(Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China)

机构地区：[1]昆明理工大学生命科学与技术学院,昆明650500

出　　处：《热带亚热带植物学报》2017年第4期394-398,共5页Journal of Tropical and Subtropical Botany

基　　金：国家自然科学基金项目(31500287);云南省人才培养项目(KKSY201326042)资助~~

摘　　要：为了解白菊木[Gochnatia decora(Kurz)A.L.Cabrera]的化学成分,从其树皮甲醇提取物的石油醚萃取部位分离出11个化合物,分别鉴定为木栓酮(1)、木栓醇(2)、齐墩果酸(3)、齐墩果烯(4)、豆甾醇(5)、β-谷甾醇(6)、棕榈酸(7)、正十五烷酸(8)、十四烷酸-1-甘油酯(9)、对羟基苯甲酸甲酯(10)和没食子酸甲酯(11),所有化合物均为首次从白菊木属植物中发现。采用脂多糖(LPS)诱导小鼠巨噬细胞RAW264.7产生一氧化氮(NO)模型和中性粒细胞弹性蛋白酶抑制试验对单体化合物1~4进行了抗炎活性测试,结果表明,化合物1、3和4具有明显的NO抑制活性(IC50<10μmol L–1),化合物2、3和4具有一定的中性粒细胞弹性蛋白酶抑制活性。In order to clarify the chemical constituents and their anti-inflammatory activities of Gochnatia decora,eleven compounds were isolated from the petroleum ether fraction of methanol extracts from the barks of G.decora.These compounds were identified as friedelin(1),friedelinol(2),oleanolic acid(3),oleanene(4),stigmasterol(5),β-sitosterol(6),palmitic acid(7),n-pentadecanoic acid(8),l-O-myristoylglycerol(9),methyl4-hydroxybenzoate(10),and methyl gallate(11).All the compounds were obtained from the genus Gochnatia for the first time.The compounds1,3and4displayed significantly high inhibitory activities against NO production(IC50<10μmol L-1),while2,3and4exhibited moderate neutrophil elastase(NE)inhibitory activities by the assay of LPS-induced NO production in RAW264.7cells and inhibition of NE,respectively.

关 键 词：白菊木 化学成分 三萜 抗炎活性 

分 类 号：R284.1[医药卫生—中药学]