98例老年人消化性溃疡的临床与病理特征分析  

作　　者：严利桃[1] 陈旭平[1] 陈霞[1] 付丹[1] 梁红亮[1] 陈炜[1] 

机构地区：[1]成都市第六人民医院消化内科,四川成都610051

出　　处：《世界中医药》2017年第A01期344-345,共2页World Chinese Medicine

摘　　要：目的探讨老年消化性溃疡与非老年消化性溃疡的临床和病理特点及异同。方法经过胃镜确诊为消化性溃疡患者200例，分为老年组(98例)和非老年组(102例)，比较2组患者的临床特点、幽门螺杆菌感染、NSAIDs使用和病理组织学特点。结果老年组不典型上腹痛和上消化道出血、休克症状比例高于非老年组；非老年组上腹节律性疼痛比例明显高于老年组；非老年组HP感染明显高于老年组，老年组NSAIDs使用比例高于非老年组；老年组病理组织学改变肠上皮化生、腺体萎缩和高级别上皮内瘤变明显高于非老年组；老年组癌变明显高于非老年组。结论老年消化性溃疡的临床表现多不典型，部分与幽门螺杆菌感染，部分有NSAIDs使用有关，约半数上皮内瘤变，少部分癌变。Objective:Aim to investigate clinical and pathological similarities and differences between the elderly peptic ulcer and non-elderly peptic ulcer.Methods:200patients with peptic ulcer diagnosed by endoscopy,were divided into old age group(98cases)and non-elderly group(102cases),then compared clinical features,Helicobacter pylori infection,NSAIDs use and pathological histological features.Results:Old age group is not typical upper abdominal pain and upper gastrointestinal bleeding,shock symptoms is higher than the non-elderly group;epigastric rhythm of pain was significantly higher in non-elderly group than in elderly group;HP infection in non-elderly group was significantly higher than the older group,NSAIDs use ratio in the elderly group is higher than the non-elderly group.In elderly group,histological changes of intestinal metaplasia,glandular atrophy and high-grade intraepithelialneoplasia(CIN)was significantly higher than the non-elderly group;cancer in the elderly group was significantly higher than the non-elderly group.Conclusion:The elderly peptic ulcer clinical manifestations are not typical.Helicobacter pylori infection and NSAIDs is a common cause of peptic ulcer of the aged.There are about half of patients with peptic ulcer of the aged found intra-epithelial neoplasia,about small part gastric cancer.

关 键 词：老年消化性溃疡 幽门螺杆菌 病理特征 临床特征 

分 类 号：R249[医药卫生—中医临床基础]