右美托咪定对神经外科术后患者全麻苏醒期躁动的临床研究  

Clinical study on the effect of dexmedetomidine on postoperative agitation in patients undergoing general anesthesia

作　　者：王玲[1] 彭洪[1] 匡显发 巫志国[1] 易萍[1] 杨文[1] Wang Ling;Peng Hong;Kuang Xian-fa;Wu Zhi-guo;Yi Ping;Yang Wen(Department of Anesthesiology, People's Hospital of Pingxiang , Pingxiang,Jiangxi, 337055, China)

机构地区：[1]萍乡市人民医院麻醉科,江西萍乡337055

出　　处：《当代医学》2017年第21期29-31,共3页Contemporary Medicine

摘　　要：目的探讨右美托咪定对神经外科术后患者全麻苏醒期躁动的影响。方法选择行颅脑外科手术患者60例,采用随机数字表法将其均分为右美托咪定组(Dex组)和对照组,各30例,Dex组围手术期给予右美托咪定,对照组给予等容量0.9%氯化钠溶液,观察比较两组患者不同时刻的心率(HR)、平均动脉压(MAP)、血氧饱和度(SpO_2)的变化及躁动的发生情况;并比较SAS评分及Ramsay评分差别。结果 Dex组拔管即刻和拔管后5 min时MAP比对照组低,HR明显减慢,差异均有统计学意义(P<0.05),两组患者SpO_2比较差异无统计学意义;Dex组患者躁动评分和躁动发生率显著低于对照组(P<0.05);拔管时,Dex组患者SAS评分比对照组低,差异有统计学意义(P<0.05);拔管后10 min,Dex组患者Ramsay评分比对照组高,差异有统计学意义(P<0.05)。结论采用右美托咪定有利于全麻患者维持血流动力学稳定,缓解拔管时及把关后患者躁动情况,减少神经外科手术患者全麻苏醒期躁动的发生,值得进一步研究。Objective To investigate the effect of dexmedetomidine on postoperative agitation in patients undergoing general anesthesia.Methods60patients underwent brain surgery,were randomly divided into dexmedetomidine group(Dex group)and control group,30cases in each group,Dex perioperative administration of dexmedetomidine,the control group received the same volume of0.9%Sodium Chloride Solution.The two groups were observed and compared the heart rate(HR),mean arterial pressure(MAP)oxygen saturation(SpO2)changes at different time and the incidence of agitation;and comparison between the two groups of SAS score and Ramsay score difference.Results Dex group of extubation and after extubation5min MAP lower than the control group,HR decreased significantly,the differences were statistically significant(P<0.05),two patients in SpO2group were not significantly different;Dex group of patients and the incidence of restlessness agitation score was significantly lower than the control group(P<0.05);when extubation,Dex of patients with SAS score lower than the control group,the difference was statistically significant(P<0.05);10min after extubation,Dex group patients with Ramsay score higher than the control group,the difference was significant(P<0.05).Conclusion The use of dexmedetomidine for anesthesia in patients with stable hemodynamics,alleviate the restlessness of patients extubation and control,reduce the incidence of agitation in patients with general anesthesia operation in the Department of Neurosurgery,it is worthy of further study.

关 键 词：右美托咪定 神经外科 全麻苏醒期 躁动 

分 类 号：R614.2[医药卫生—麻醉学]