山莨菪碱(654-2)治疗早产儿感染性休克  

Scopolamine(654-2) and Phenol Tolamine Treat for Premature Infant Infectious Shock

作　　者：郭玥馨[1] GUO Yue-xin(The university of zhengzhou affiliated luoyang central hospital pediatrics, Luoyang Henan 471000,China)

机构地区：[1]郑州大学附属洛阳中心医院儿科,河南洛阳471000

出　　处：《药品评价》2017年第14期46-48,共3页Drug Evaluation

摘　　要：目的:探讨山莨菪碱(654-2)、酚妥拉明治疗早产儿感染性休克的临床效果。方法:选取我院2015年2月—2017年2月收治的感染性休克早产儿40例作为研究对象,根据临床治疗方法的不同,分为对照组与研究组。每组患儿各20例。对照组患儿使用酚妥拉明药物进行治疗,研究组患儿在对照组使用酚妥拉明基础上联合山莨菪碱(654-2)进行治疗。对比两组患儿临床治疗前后细胞因子变化情况。结果:两组患儿血浆IL-6、IL-8、TNF-α和CRP含量较治疗前后均有显著下降,研究组的下降值明显大于对照组(P>0.05)。结论:早产儿感染性休克临床治疗中,使用酚妥拉明联合山莨菪碱(654-2)可以有效改善患儿血液动力学和肾功能,临床治疗效果显著,但是若单独使用山莨菪碱(654-2)或酚妥拉明临床效果则会有所下降。Objective:To investigate the clinical efficacy of anisodamine(654-2)and phentolamine in the treatment of septic shock in premature infants.Methods:40cases of infectious shock premature infants treated in our hospital from February2015to February2017were selected as the research object.According to the different methods of clinical treatment,they were divided into the control group and the study group.There were20children in each group.The children in the control group were treated with phentolamine,and the patients in the study group were treated with anisodamine(654-2)on the basis of phentolamine.The changes of cytokines before and after clinical treatment were compared between the two groups.Results:Plasma IL-6,IL-8,TNF-alpha and CRP content was decreased significantly after treatment in both of the two groups,while the study group decreased more obvious compared with the control group(P<0.05).Conclusion:Phentolamine combined with anisodamine(654-2)can effectively improve hemodynamics and renal function for infections of premature infants in shock.The clinical effect is remarkably decreased if only use anisodamine(654-2)or phentolamine alone.

关 键 词：山莨菪碱(654-2) 酚妥拉明 治疗 早产儿 感染性休克 

分 类 号：R722.6[医药卫生—儿科]