血清淀粉样蛋白A联合C反应蛋白对儿童甲型流感早期诊断价值的评价  

Early diagnostic value of serum amyloid A combined with C-reactive protein in diagnosis of influenza A in children

作　　者：廖嘉仪 张涛 LIAO Jiayi;ZHANG Tao(Department of Respiration,Guangzhou Yuexiu District Children′s Hospital Guangzhou 510115,China)

机构地区：[1]广州市越秀区儿童医院呼吸科,510115

出　　处：《实用医学杂志》2017年第14期2368-2370,共3页The Journal of Practical Medicine

基　　金：广东省医学科研基金(编号:B2014351);广州市医药卫生科技项目(编号:2009-YB-177)

摘　　要：目的探讨血清淀粉样蛋白A(SAA)、C反应蛋白(CRP)和SAA/CRP比值在早期诊断儿童甲型流感的临床应用价值。方法选取2016年4-6月诊断为甲型流感的139例患儿为研究对象,另选取健康儿童278例为对照组,检测两组儿童SAA、CRP、SAA/CRP比值、白细胞(WBC)等指标水平,采用受试者工作特征曲线(ROC)分析各指标对甲流的诊断价值。结果甲型流感患儿SAA、CRP水平以及SAA/CRP比值显著高于健康对照组(P<0.001),其中SAA、SAA/CRP比值的ROC曲线下面积(AUC)均>0.7,且差异有统计学意义(P<0.001)。当SAA为10.500 mg/L,敏感度为85.5%,特异度96.8%;当SAA/CRP比值为6.165,敏感度为55.4%,特异度91.4%。结论 SAA与CRP联合检测对早期诊断儿童甲型流感具有一定的价值,其中SAA的价值最高。Objective To evaluate the clinical value of serum amyloid protein(SAA),C?reactive protein(CPR)and SAA/CRP ratio in early diagnosis of influenza A in children.Method SAA,CRP,SAA/CRP ratioand serum white blood cell(WBC)count were measured in417children.One hundred and thirty?nine children were diagnosed with Influenza A and were enrolled in the influenza A group,and the other278healthy children were enrolled in the control group from April2016to June2016.The values of the screened biomarkers for diagnosis of influenza A were assessed by ROC curve analysis.Results Levels of SAA,CRP and SAA/CRP ratio in the influenza A group were significantly higher than those in the control group(P<0.001,respectively).The areas under the ROC curve of SAA and SAA/CRP ratio for the diagnosis of influenza A were higher than0.7(P<0.001).The optimal cut?off values of SAA and SAA/CRP ratio for the diagnosis of Influenza A were10.500mg/L and6.165,respectively.The corresponding sensitivities of the optimal cut?off values for the diagnosis of influenza A were85.5%and55.4%,respectively,and the corresponding specificities were96.8%and91.4%,respectively.Conclusion Measurement of SAA and SAA/CRP ratio are valuable biomarkers for clinical in early diagnosis of influenza A and SAA has a better diagnostic performance than CRP.

关 键 词：甲型流感 血清淀粉样蛋白A C反应蛋白 早期诊断 儿童 

分 类 号：R446.1[医药卫生—诊断学] R725.1[医药卫生—临床医学]