精准医学背景下CTC检测的应用  

Application of CTC Detection in Precision Medical Background

作　　者：高阳[1,2] 张景春[3] 康熙雄[1] GAO Yang;ZHANG Jing-chun;KANG Xi-xiong(Capital Medical University Beijing Tiantan Hospital Laboratory Diagnosis Department,Beijing 100020;Hangzhou Waston Biotech. INC,Zhejiang Hangzhou 310051;Jilin Univercity China-Japan Fellowship Hospital,Jilin Changchun 130033)

机构地区：[1]首都医科大学附属北京天坛医院首都医科大学检验诊断学系,北京100020 [2]杭州华得森生物技术有限公司,浙江杭州310051 [3]吉林大学附属中日联谊医院,吉林长春130033

出　　处：《中国医疗器械信息》2017年第11期14-17,共4页China Medical Device Information

摘　　要：精准医学是随着科学技术不断发展,人们对健康需求的不断提高,而逐渐兴起的新的医疗理念和模式,主要基于分子病理医学和最先进的医学检测技术,通过对患者进行基因组、转录组、蛋白组、表观遗传学、分子影像学和分子病理学检测,结合患者病例病理信息,为患者制定针对个体疾病特征的最优化治疗方案,以追求最大的治疗效果和最低毒副作用。肿瘤精准医学的发展方向之一就是无创诊疗,其中液体活检愈来愈受医疗诊断业界关注,液体活检通过无创方式检测体液(主要为外周血、唾液、尿液、胸腹腔积液等)中的循环肿瘤细胞(CTC)、循环肿瘤DNA(ctDNA)、外泌体(Exsome)等肿瘤来源的生物标志物,动态反应肿瘤的疾病进展,为肿瘤的早期诊断、预后评估、疗效监测、复发转移检测、实时动态监测和个体化诊疗等,为肿瘤诊疗提供了一种简便快捷的手段。Precision medicine is a new medical concepts and models,which gradual rise with the continuous development of science and technology,and the people'shealth needs.It mainly based on molecular pathology and the most advanced medical testing technology,through the genomics,proteomics,epigenetics,molecular imaging and molecular pathology,combined with patient case and pathology information,for patients with the development of individual disease forthe characteristics of the optimal treatment program,to pursue the greatest therapeutic effect and the lowest side effects.One of the directions of developmentof tumor precision medicine is noninvasive diagnosis,in which liquid biopsy is increasingly concerned by the medical diagnosis.Liquid biopsy provides asimple and quick means for cancer diagnosis and treatment,by detecting the circulating tumor cell(CTC),circulating tumor DNA(ctDNA),exosomes andother tumor-derived biomarkers,which come from body fluids(mainly peripheral blood,saliva,urine,pleural effusion,etc.),in a relatively noninvasiveway,dynamic response of tumor disease progression,for the early diagnosis of cancer,prognosis evaluation,efficacy monitoring,recurrence and metastasisdetection,real-time dynamic monitoring and individual diagnosis and treatment.

关 键 词：精准医学 液体活检 循环肿瘤细胞 

分 类 号：R197.39[医药卫生—卫生事业管理]