晕痣与白癜风致病机理免疫学对比分析研究  

Comparative Study on the Pathogenesis and Immunology of Nevus and Vitiligo

作　　者：宋鹏飞[1] 陈加媛[1] 贺勤[1] 徐娟[1] 王京[1] SONG Pengfei;CHEN Jiayuan;HE Qin;XU Juan;WANG Jing(Department of Dermatology, The Eighth Affiliated Hospital of Zhongshan University,Shenzhen Guangdong 518000, China)

机构地区：[1]中山大学附属第八医院皮肤科,广东深圳518000

出　　处：《中国卫生标准管理》2017年第16期63-65,共3页China Health Standard Management

基　　金：深圳市科技计划项目(项目编号:JCYJ20140416094256893);深圳市福田区卫生公益科研项目(项目编号:FTWS2014001)

摘　　要：目的对比分析晕痣与白癜风致病机理免疫学,完善院内对晕痣与白癜风的治疗方法。方法根据我院2014年1月—2017年1月所收治的220例白癜风患者的临床治疗资料,进行回顾性分析,做白介素-6、白介素-8和血清抗黑素细胞Ig G抗体检测,对晕痣发生情况进行分析和探究。结果白癜风与晕痣的发作与患者机体免疫能力具有正相关性,抗黑素细胞Ig G是指示白癜风免疫学成病原因的重要指标,晕痣可诱发白癜风,白癜风不一定会并发晕痣。进展期白癜风患者的抗黑素细胞Ig G和细胞因子对比正常指标,差异具有统计学意义(P<0.05)。结论白癜风与患者自身免疫能力成正相关性,晕痣可导致白癜风,白癜风与晕痣在免疫学致病机制上具有相似性,泛发性白癜风患者晕痣发生概率较高。Objective To compare and analyze the pathogenesis and immunology of halo nevus and vitiligo,and to improve their clinical treatment.Methods The clinical data of220cases of vitiligo patients in our hospital collected from January2014to January2017were analyzed retrospectively,and the concent of IL-6,IL-8and interleukin melanocyte IgG antibody were detected.Results The onset of vitiligo and halo nevus had a positive correlation with patients'immunity.Anti melanocyte IgG was an important immunology indicator of vitiligo into disease causes.Halo nevus could induce vitiligo,however,vitiligo may not induce halo nevus.There was a significant difference between the normal indexes of anti melanocyte IgG and cytokine in patients with advanced vitiligo(P<0.05).Conclusion Vitiligo are positively related with autoimmune ability,halo nevus can lead to vitiligo,vitiligo is similar in the pathogenesis of immunology with halo nevus,and generalized vitiligo patients have a higher probability of halo nevus.

关 键 词：晕痣 白癜风 抗黑素细胞IgG抗体 细胞因子 临床研究 

分 类 号：R758[医药卫生—皮肤病学与性病学]