噻唑并[3,2-a]嘧啶-5-酮衍生物的合成及其对Fe^(3+)的识别  

Synthesis and recognition of Fe^(3+) based on thiazolo[3,2-a] pyrimidin-5-one derivatives

作　　者：钟克利[1] 陈东雪 陈召年 邹迎晖 王道林[1] 汤立军[1] ZHONG Ke-li;CHEN Dong-xue;CHEN Zhao-nian;Z0U Ying-hui;WANG Dao-lin;TANG Li-jun(College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121013 ,China)

机构地区：[1]渤海大学化学化工学院,辽宁锦州121013

出　　处：《化学研究与应用》2017年第2期211-216,共6页Chemical Research and Application

基　　金：国家自然科学基金项目(21304009;21476029)资助;辽宁省高等学校优秀人才支持计划项目(LJQ2014125;LR2015001)资助

摘　　要：以丁二酸酐、三乙二醇单甲醚为原料,经酯化、酰化后与7-(3-氨基噻吩并[2,3-b]吡啶-2-基)-噻唑并[3,2-a]嘧啶-5-酮反应,制备荧光探针L,利用核磁和质谱对其结构进行了表征。该探针L可在HEPES溶液中荧光"开-关"识别Fe^(3+),pH在3.4~6.4范围内识别效果较好,其他金属离子没有干扰,检测限可达2.534×10^(-4)M。The probe L was successfully synthesized by esterification and acylation utilizing succinic anhydride with triethylene gly-col monomethyl ether,and then nucleophilic substitution with7-(3-aminothieno[2,3-6]pyridin-2-yl)thiazolo[3,2-a]pyrimidin-5-one.The structure of L was characterized by NMR and Mass spectrum.The fluorescent probe L displays highly selective recognition of Fe3+with a fluorescenceaON-OFF”response in buffered aqueous solution(HEPES1x103mol?L1,pH=6.4).The low limit of detection(2.534x104M),a wide usable pH range from3.4to6.4and non-interference from the other metal ions make it po-tentially applicable for determining Fe3+in aqueous solution.

关 键 词：杂环化合物 合成 Fe3+离子 荧光探针 识别 

分 类 号：O657.3[理学—分析化学]