缺血性卒中后抑郁患者静息状态下默认网络功能连接的研究  

Resting-state functional magnetic resonance imaging study of ischemic post stroke depression

作　　者：张佩瑶[1] 徐琴[2] 王君[3] 王晶[4] 戴建平[5] ZHANG Pei-yao;XU Qin;WANG Jun;WANG Jing;DAI Jian-ping(Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China;Department of Medical Imaging, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China;State Key Laboratory of Cognitive Neuroscience and Learning &IDG/Mc Govern Institute for Brain Research, Beijing Normal University, Beijing 100875, China;Department of Neurology, Beijing Tiantan Hospital, Capital Medical University,Beijing 100050, China;Department of Neuroimaging, Beijing Tiantan Hospital, Capital Medical University,Beijing 100050, China)

机构地区：[1]1中日友好医院放射科,北京100029 [2]广州中医药大学第一附属医院影像科,广州510405 [3]北京师范大学认知神经科学与学国家重点实验室,北京100875 [4]首都医科大学附属北京天坛医院神经内科,北京100050 [5]首都医科大学附属北京天坛医院神经影像中心,北京100050

出　　处：《磁共振成像》2017年第6期401-407,共7页Chinese Journal of Magnetic Resonance Imaging

摘　　要：目的利用静息态功能磁共振成像(resting-state functional magnetic r e s o n a n c e i m a g i n g,r s-f M R I)技术,研究缺血性卒中后抑郁(p o s t s t r o k e depression,PSD)患者静息状态下默认网络(default mode network,DMN)功能连接的变化。材料与方法选取13例发病在两周内、汉密尔顿抑郁量表(hamilton depression scale,HAMD)评分>7分且为首发抑郁的PSD患者,同时选择13名正常被试作为对照组(control)分别进行静息态f MRI扫描。分别选取双侧楔前叶作为感兴趣区(region of interest,ROI),计算并比较两组被试默认网络功能连接的变化。结果与正常被试相比,PSD患者双侧顶下小叶、双侧额颞叶与右侧楔前叶功能连接减低;右侧顶下小叶、双侧额颞叶与左侧楔前叶功能连接减低,而未发现功能连接显著增高的脑区。结论默认网络功能连接的变化可能与卒中后抑郁的发生具有相关性。Objective:To investigate the altered functional connectivity(FC)ofthe default mode network(DMN)in patients with post ischemic stroke depression.Materials and Methods:Thirteen PSD patients and13matched normal controls wererecruited and the resting-state fMRI images were acquired on a3.0T Siemens MRIscanner.The datasets were analyzed using SPM8and REST.The bilateral precuneuswere selected as regions of interest(ROIs),and functional connectivity was calculatedand compared between PSD patients and normal controls.Results:The FCs of theDMN was altered in PSD patients compared to normal controls.The brain areas whichshowed decreased FCs including the bilateral inferior parietal lobule,bilateral frontallobule and bilateral temporal lobule.However,the increased FC has not been found inthe current study.Conclusion:Dysfunction of the DMN may be associated with thedevelopment of PSD.

关 键 词：卒中 抑郁症 默认网络 功能连接 磁共振成像 功能 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743.3[医药卫生—诊断学]