哈萨克族原发性高血压患者血清胆红素及血脂水平的分析  

Analysis of serum bilirubin and blood lipid levels in Kazak patients with essential hypertension

作　　者：陶杰[1] 王忠[2] 陈少泽[2] 张明[1] 张卫华[1] TAO Jie;WANG Zhong;CHEN Shao-ze;ZHANG Ming;ZHANG Wei-hua(Medical College of Shihezi University,Shihezi 832002,China;The First Affiliated Hospital,Medical College,Shihezi University,Shihezi 832002,China))

机构地区：[1]石河子大学医学院,新疆石河子832002 [2]石河子大学医学院第一附属医院,新疆石河子832002

出　　处：《东南大学学报（医学版）》2017年第2期209-213,共5页Journal of Southeast University(Medical Science Edition)

基　　金：国家自然科学基金资助项目(81460075)

摘　　要：目的:研究哈萨克族原发性高血压(EH)患者血清胆红素与血压、血脂的关系,并探讨胆红素水平的性别差异。方法:选取2014年11月至2015年4月接受流行病学调查的新疆哈萨克族人群267人作为研究对象,根据血压分为EH组(128例)和血压正常组(139例),对比分析各组总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),计算体重指数(BMI);另外根据性别将两组人群各分为两个亚组,对比分析各组血清胆红素水平。结果:与正常组比较,EH组TBIL、DBIL均较低(P<0.05),年龄、BMI、TC、LDL-C均较高(P<0.05)。各亚组组间比较,EH组女性较正常组女性TBIL、DBIL、IBIL均降低(P<0.05),较EH组男性,TBIL、DBIL均降低(P<0.05)。相关分析显示TBIL、DBIL与LDL-C呈负相关(r分别为-0.176、-0.233,P均<0.05),DBIL与TC呈负相关(r=-0.192,P<0.05)。结论:新疆哈萨克族EH患者的血清胆红素水平降低,BMI、TC、LDL-C升高;血清总胆红素及直接胆红素与血压有一定的相关性,并可能是哈萨克族女性患EH的危险因素;血清TBIL、DBIL可能是通过影响血脂代谢而影响血压的。O b jective:To investigate the relationship between serum bilirubin levels and blood pressure,the Kazak patients with essential hypertension(EH),and explore the gender diferences of serum bilirubin M eth o d s:128cases of EH and139cases of healtli controls were collected from Xinjiang Kazak epidemiological investigation from November2014to April2015,the serum total bilirubin(TBIL),direct bilirubin(DBIL),indirect bilirubin(IBIL),triglycerides(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL_C)#high density lij^oprotein cholesterolHDL_C)were measured,and body mass index(BM I)were calculated$and the serum bilirubin levels were analyzed in male and women groups.R esults%The T B IL,D B IL in EHgroup were lower than those in control group!P<0-05),but tlie age,B M I,TC,LDL-C were higher(P<0.05).The T B IL,D BIL,IBIL in women EHgroup were lower than those in women control and the male in EH group!!Y0.05).Pearson relation analysis showed that TBIL and DBIL were negatively correlated with LDL_C(3values were-0.176,-0.233,respectively,P<0.05,overall),and DBIL also negatively correlated with TC(3=-0?192,!<0.05).C onclusion%The serum TBIL and DBIL have a certain correlation with blood pressure,and may becomea risk factors for women of the Kazak patients with EH$Serum TBIL and DBIL may affect the blood pressurethrough blood lipid metabolism.

关 键 词：原发性高血压 哈萨克族 血清胆红素 体重指数 血脂 性别 

分 类 号：R544.11[医药卫生—心血管疾病]