低温脑保护的分子学机制  

The molecular mechanisms of hypothermia cerebral protection

作　　者：王晶[1] 陈翀[1] 李晓红[1] WANG Jing;CHEN Chong;LI Xiao-hong(Institute of Traumatic Brain Injury and Neurology, Logistics University of Chinese People’s Armed Police Forces,Key Laboratory of Neurotrauma Repair of Tianjin, Tianjin 300162, China)

机构地区：[1]武警后勤学院附属医院脑创伤与神经疾病研究所,天津市神经创伤修复重点实验室,300162

出　　处：《天津医药》2017年第8期845-850,共6页Tianjin Medical Journal

基　　金：国家自然科学基金资助项目(81471275,81401067,81541034);天津市自然科学基金资助项目(15JCQNJC11100,15JCYB-JC28100,16JCYBJC27600)

摘　　要：低温治疗也称目标温度管理(TTM),是指将身体核心体温降至32~35℃。轻、中度低温治疗可有效应用于缺血性脑病、颅脑创伤、出血性卒中及其他形式的严重脑损伤等,发挥神经保护作用。急性脑损伤、脑缺血引发的级联反应复杂多样,目前的研究显示低温治疗发挥脑保护作用主要是从抑制代谢紊乱、兴奋性毒性、氧化应激反应、细胞凋亡、炎症反应、促进神经元再生以及维持血脑屏障完整性等方面来实现的。深入探讨低温治疗发挥神经保护作用的分子机制有助于临床工作者更好地理解及完善低温治疗的适应证及禁忌证,并为其他治疗方法与低温疗法协同应用提供理论储备及临床实践可能。Therapeutic hypothermia(TH),also known as targeted temperature management(TTM),is the intentionalreduction of core body temperature to32-35℃.Mild-to-moderate hypothermia and advanced cooling technology can be used as an effective component of multimodal therapy for ischemic encephalopathy,brain trauma,haemorrhagic stroke,orother forms of severe brain injury and acute neurological injuries to achieve neuroprotection.The events occured after anepisode of acute neurological injuries and cerebral ischemia are multiple.And the possible explanation for theneuroprotective benefits of hypothermia therapy is inhibiting metabolic disruption,excitotoxicity,oxidative stress,cellapoptosis signals,inflammatory responses,and promoting neuronal integrity and blood-brain barrier integrity.To know themolecular mechanisms of action of TH,which exerts neuroprotective function,will provide clinicians a better understandingthe indications and contraindications of this therapy,and provide a possible theoretical reserves and clinical practice forother therapies when used in conjunction with hypothermia.

关 键 词：脑损伤 低温治疗 脑保护 分子学机制 

分 类 号：R318.52[医药卫生—生物医学工程] R651.15[医药卫生—基础医学]