The 12th China-Japan Joint Seminar on Histochemistry and Cytochemistry  

出　　处：《中国组织化学与细胞化学杂志》2017年第4期403-428,共26页Chinese Journal of Histochemistry and Cytochemistry

摘　　要：01 Differentiation-dependent changes in DNA methylation and histone H3 acetylation: possible roles of these epigenetic factors in mouse spermatogenesis Takehiko Koji Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan Mammalian spermatogenesis is a well-ordered process, consisting of spermatogonial mitosis, spermatocytic meiosis and spermiogenesis.The process is also characterized by successive chromatin condensation and a high frequency of spermatogenic cell apoptosis.Therefore, epigenetic factors can be implicated in the regulation of spermatogenesis and any epigenetic disorder may lead to the induction of apoptosis. When we analyzed global level of DNA methylation by immunohistochemistry with anti-5-methylcytosine in paraffin-embedded sections of mouse testis, there was no difference among any stages of germ cells.

关 键 词：CYTOCHEMISTRY HISTOCHEMISTRY Cell BIOLOGY 

分 类 号：R34[医药卫生—基础医学]