不同剂量阿托伐他汀对AMI的疗效及对血小板、BNP和CRP水平的影响  

Effects of different doses of atorvastatin on levels of platelet, BNP and CRP in patients with acute myocardial infarction

作　　者：闫少迪[1] YAN Shaodi(Sun Yixian Cardiovascular Hospital of Shenzhen City,Shenzhen 518000,China)

机构地区：[1]深圳市孙逸仙心血管医院,广东深圳518000

出　　处：《中国医药科学》2017年第15期67-69,138,共4页China Medicine And Pharmacy

摘　　要：目的不同剂量阿托伐他汀对急性心肌梗死(AMI)的疗效及对血小板、脑钠肽(BNP)和C反应蛋白(CRP)水平的影响。方法回顾性分析2016年1月~2017年3月我院收治的110例AMI患者的临床资料,根据阿托伐他汀的使用剂量分为小剂量组(n=34)和大剂量组(n=76)。两组入院后均予以AMI常规治疗,在此基础上,小剂量组予以阿托伐他汀,20mg/次,1次/d;大剂量组予以阿托伐他汀,80mg/次,1次/d。比较两组治疗前后的血小板计数、血小板聚集率、血小板粘附率,血清BNP和CRP水平,以及临床疗效和不良反应。结果治疗后,两组患者血小板聚集率、血小板粘附率,血清BNP和CRP水平均较治疗前显著降低,且大剂量组各指标降低更显著,差异有统计学意义(P<0.05)。两组不良反应发生比较差异无统计学意义(P>0.05)。结论大剂量阿托伐他汀80mg可明显提高对AMI的治疗效果,改善患者血小板、BNP和CRP指标,且无明显不良反应,值得推广应用。Objective To investigate the effects of different doses of atorvastatin on levels of platelet,brain natriuretic peptide(BNP)and C-reactive protein(CRP)in patients with acute myocardial infarction(AMI).Methods The clinical data of110patients withAMI that treated in our hospital from January2016to March2017were retrospectively analyzed.All patients were divided into small dosegroup(n=34)and large dose group(n=76)according to different doses of atorvastatin.The patients of wo groups were treated with AMIconventional treatment after admission,and on this basis,the patients in the small dose group were treated with atorvastati while patientsin the large dose group were treated with atorvastatin(80mg/times,1times/d).The levels of platelet count,platelet aggregation rate,platelet adhesion rate,serum BNP and CRP,clinical efficacy and adverse cardiovascular events were compared between the twogroups before and after treatment.Results After treatment,the levels of platelet aggregation rate,platelet adhesion rate,serumBNP and CRP in two groups were significantly decreased than before the treatment(P<0.05).The indexes in the large dosegroup were decreased more significantly than small dose group,the difference was statistically significant(P<0.05).There wereno significant differences in adverse reactions between two groups(P<0.05).Conclusion High dose atorvastatin(80mg)cansignificantly increase the clinical effects of AMI patients,improve the platelet,BNP and CRP,and no obvious adverse reactions.It isworthy of popularization and application.

关 键 词：阿托伐他汀 急性心肌梗死 血小板 脑钠肽 C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]