胰高血糖素样肽-1的肾脏保护作用及机制  

Protective Effects of Glucagon-like Peptide-1 in Kidney

作　　者：庞萍[1,2] 臧丽[1,2] 吕朝晖[2] PANG Ping;ZANG Li;LYU Zhao-hui(Department of Endocrinology, Hainan branch of Chinese PLA General Hospital, Sanya Hainan 572013, China;Department of Endocrinology,Chinese PLA General Hospital, Beijing 100853)

机构地区：[1]解放军总医院海南分院内分泌科,海南三亚572013 [2]解放军总医院内分泌科,北京100853

出　　处：《药品评价》2017年第13期13-17,24,共6页Drug Evaluation

基　　金：北京市自然科学基金(项目编号:7172196);解放军总医院科技创新苗圃基金(项目编号:14KMM05)

摘　　要：胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)是小肠L细胞分泌的肠促胰素,通过刺激胰岛素分泌和抑制胰高血糖素释放等机制降低血糖。近年来越来越多的研究显示GLP-1具有独立于降糖之外的肾脏保护作用。GLP-1的肾脏保护作用可能是多重机制共同作用的结果,包括GLI-1受体(glucagon-like peptide-1 receptor,GLP-1R)依赖性和非依赖性途径,其中受体依赖性途径更重要。Glucagon-like peptide-1(GLP-1)is an incretin hormone secreted from enteroendocrine L cells,which control glycemia by stimulatinginsulin synthesis and inhibiting glucagon secretion.Several studies have shown that GLP-1has renal protective effects independent of glycemiccontrol.The renal protective effects were mediated via several pathways,including GLP-1/GLP-1R dependent and independent mechanisms.

关 键 词：胰高血糖素样肽-1 胰高血糖素样肽-1受体 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]