血清胎球蛋白A水平变化与代谢综合征的相关性  

Correlation of the changes of serum alpha2-Heremans-Schmid glycoprotein levels with metabolic syndrome

作　　者：季红兵[1] 居会祥[1] 孙明忠[1] 陈红梅[1] 韩玉清[1] 周中卫[1] JI Hongbing;JU Huixiang;SUN Mingzhong;CHEN Hongmei;HAN Yuqing;ZHOU Zhongwei(Department of Clinical Laboratory,Yancheng Hospital,Southeast University School of Medicine,Yancheng 224001,Jiangsu,China)

机构地区：[1]东南大学医学院附属盐城医院检验科,江苏盐城224001

出　　处：《检验医学》2017年第8期677-681,共5页Laboratory Medicine

基　　金：盐城市科技局科技发展计划项目(YK2015115)

摘　　要：目的探讨血清胎球蛋白A(AHSG)水平变化与代谢综合征(MS)的相关性。方法收集726名体检者的相关临床资料[腰围、血压、体重指数(BMI)、空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、C反应蛋白(CRP)、胰岛素抵抗指数(HOMA-IR)及游离脂肪酸(FFA)],采用酶联免疫吸附试验测定AHSG水平。根据美国胆固醇教育计划成人治疗方案第3次报告(NCEP-ATPⅢ)(2005修订版)的标准,726名体检者中确诊211例MS患者。比较MS组和非MS组各项指标的差异。采用Pearson相关分析及多元线性回归分析评估AHSG与各临床参数间的关系,采用Logistic回归分析评估AHSG各四分位水平与MS相对危险度的关系,采用受试者工作特征(ROC)曲线评估AHSG对MS的诊断价值。结果 MS组血清AHSG水平明显高于非MS组(P<0.05),其他各项指标2个组间差异均有统计学意义(P<0.05、P<0.01)。相关性分析显示,AHSG与腰围、FPG、TG、LDL-C、CRP、HOMA-IR及FFA均呈正相关(r值分别为0.094、0.133、0.107、0.078、0.088、0.126及0.119,P<0.05),与腰围、CRP及HOMA-IR呈独立正相关(β值分别为0.088、0.083及0.091,P值分别为0.022、0.033及0.014)。Logistic回归模型中,MS的发生风险随AHSG四分位水平的增高而增加(P<0.01)。ROC曲线分析显示,AHSG诊断MS的ROC曲线下面积为0.709,临界值为285.3μg/m L,敏感性为70.5%,特异性为73.8%。结论高水平的AHSG是MS的风险因素,对MS有一定的临床价值。Objective To investigate the correlation of the changes of serum alpha2-Heremans-Schmid glycoprotein(AHSG)levels with metabolic syndrome(MS).Methods A total of726subjects were enrolled.Their clinical data[waist circumference,blood pressure,body mass index(BMI),fasting plasma glucose(FPG),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),C-reactive protein(CRP),homeostasis model assessment for insulin resistance(HOMAIR)and free fatty acid(FFA)]were collected,and serum levels of AHSG were determined by enzyme-linked immunosorbent assay.A total of211of726subjects were identified with MS,according to the revision of the Adult Treatment PanelⅢof the National Cholesterol Education Program(NCEP-ATPⅢ)in2005.The parameters were compared between MS and non-MS groups.The relation between AHSG and parameters was analyzed by Pearson correlation analysis and multiple linear regression analysis.The quartiles of AHSG and the relative risk of MS were evaluated by Logistic regression analysis,and receiver operating characteristic(ROC)curve was used to assess the role of AHSG for the diagnosis of MS.Results Serum AHSG level was higher in MS group than that in non-MS group(P<0.05),and there was statistical significance for the other parameters between the2groups(P<0.05,P<0.01).AHSG was positively correlated with waist circumference,FPG,TG,LDL-C,CRP,HOMA-IR and FFA(r=0.094,0.133,0.107,0.078,0.088,0.126and0.119,P<0.05),and was correlated independently with waist circumference,CRP and HOMA-IR(β=0.088,0.083and0.091,P=0.022,0.033and0.014).The risk of MS increased with increasing quartiles of AHSG in Logistic regression analysis(P<0.01).ROC curve showed that the area under the curve was0.709,and the cut-off value was285.3μg/mL.The sensitivity was70.5%,and the specificity was73.8%.Conclusions Increased AHSG level is one of risk factors for MS,and it plays a role for predicting the incidence of MS.

关 键 词：胎球蛋白A 代谢综合征 相关性 

分 类 号：R446.1[医药卫生—诊断学]