缓释骨形态发生蛋白-2促进骨修复的生物相容性载体研究进展  

Research and Application of Biocompatibility Carrier for Sustained-Release of Bone Morphogenetic Protein-2

作　　者：郑志强[1,3] 雷杨[1,3] 尤庆亮[3] 田玉[3] 张正涛[1] 何荣祥 陈勇[1,2] 张玮莹[1] 曹一平[1,3] ZHENG Zhiqiang;LEI Yang;YOU Qingliang;TIAN Yu;ZHANG Zhengtao;HE Rongxiang;CHEN Yong;ZHANG Weiying;CAO Yiping(Institute for Interdisciplinary Research;Département de Chimie,Ecole Normale Supérieure,24 Rue Lhomond,F-75231 Paris Cedex 05,France;Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education,Jianghan University,School of Chemistry and Environmental Engineering,Wuhan 430056,Hubei,China)

机构地区：[1]江汉大学交叉学科研究院 [2]巴黎高等师范学院化学系,巴黎75231 [3]江汉大学光电化学材料与器件教育部重点实验室,化学与环境工程学院,湖北武汉430056

出　　处：《江汉大学学报（自然科学版）》2017年第4期307-316,共10页Journal of Jianghan University：Natural Science Edition

基　　金：国家自然科学基金青年基金资助项目(31600801)

摘　　要：骨形态发生蛋白-2(bone morphogenetic protein-2,BMP-2)属于转化因子,是一种多功能生长因子,在细胞增殖、分化迁移和重建方面具有重要作用。在临床骨缺损修复中,BMP-2是参与体内骨修复至关重要的促进因子。一方面,由于BMP-2在体内的稳定性不强;另一方面,如果无载体保护,其在移植处的释放扩散形式呈"爆炸式"。而骨生长分化是一个动态的过程,因此需要建立一个可控的缓释载体。介绍了目前已应用的4种BMP-2控制释放载体,包括水凝胶和微囊、层层自组装(layer-by-layer self-assembly,LbL)、表面微处理的钛金属以及静电纺丝纤维。Bone morphogenetic protein-2(BMP-2)is a transforming factor and is a multifunctional growth factor,which plays an important role in cell proliferation,differentiation,migration and reconstruction.BMP-2is an important stimulative factor of bone repairing in the clinic application.However,BMP-2is unstable in vivo,and one common problem is the burst release at very early stages without the protection of a carrier.The growth and differentiation of bone are dynamic processes.Therefore,a controllable release carrier is needed to prevent the burst release.In this paper,we described four controllable release carriers of BMP-2,including hydrogel and microcapsule,layer-bylayer self-assembly(LbL),surface micro processing of titanium and electrospinning.

关 键 词：骨形态发生蛋白-2 控制释放 骨修复 

分 类 号：R318[医药卫生—生物医学工程]