260例产妇分娩前检测凝血四项、D-二聚体及血小板的临床分析  

Clinical analysis of four items of blood coagulation,D-dimer and platelet detection in 260 puerpera before delivery

作　　者：景阳[1] 丁萌[2] 付久园[3] 肖艳平[3] 陈向华[2] 张青云[1] JING Yang;DING Meng;FU Jiu-yuan(Department of General Surgery, Chengde Medical College Affiliated Hospital, Chengde 067000, China;Department of General Surgery, Chengde Medical College Affiliated Hospital, Chengde 067000, China;Department of General Surgery, Chengde Medical College Affiliated Hospital, Chengde 067000, China)

机构地区：[1]承德医学院附属医院血管普外科,067000 [2]承德医学院附属医院检验科,067000 [3]承德医学院附属医院产科,067000

出　　处：《中国现代药物应用》2017年第17期16-18,共3页Chinese Journal of Modern Drug Application

基　　金：2015年承德市科学技术研究与发展计划项目(项目编号:20157061)

摘　　要：目的分析产妇分娩前检测凝血四项、D-二聚体及血小板的临床意义。方法 260例产妇,根据是否伴有疾病分为正常妊娠组(120例)和妊娠伴其他疾病组(140例)。两组产妇分娩前检测凝血四项[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原定量(FIB)]、D-二聚体(DD)及血小板计数(PLT),比较两组产妇的凝血四项、D-二聚体、血小板计数水平。结果正常妊娠组产妇D-二聚体水平为(0.32±0.20)mg/L、纤维蛋白原定量水平为(4.00±1.80)g/L,均显著低于妊娠伴其他疾病组产妇的(0.48±0.21)mg/L、(4.80±1.90)g/L,差异具有统计学意义(P<0.05)。正常妊娠组凝血酶原时间、活化部分凝血活酶时间明显长于妊娠伴其他疾病组产妇,差异具有统计学意义(P<0.05)。两组产妇凝血酶时间比较差异无统计学意义(P>0.05)。正常妊娠组产妇血小板计数为(155.6±47.6)×109/L,明显高于妊娠伴其他疾病组产妇的(142.7±45.8)×109/L,差异具有统计学意义(P<0.05)。结论产妇在产前进行凝血四项、D-二聚体、血小板计数指标检查,能够对产妇的凝血功能进行判定,对产妇产前出血及产后出血的诊治起到指导作用,对预防弥散性血管内凝血(DIC)及血栓栓塞性疾病具有重要的指导意义。Objective To analyze the clinical significance of four items of blood coagulation,D-dimer and platelet detection before delivery.Methods A total of260pregnant women were divided by whether accompanied by disease into normal pregnancy group(120cases)and pregnancy with other diseases group(140cases).Detection were made on four items of blood coagulation[prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(FIB)],D-dimer(DD)and platelet count(PLT)before delivery,and comparison were made on four items of blood coagulation,D-dimer and platelet detection level in two groups.Results Normal pregnancy group had D-dimer as(0.32±0.20)mg/L,fibrinogen quantification level as(4.00±1.80)g/L,which were obviously lower than(0.48±0.21)mg/L and(4.80±1.90)g/L in pregnancy with other diseases group,and their difference had statistical significance(P<0.05).Normal pregnancy group had longer prothrombin time and activated partially thromboplastin time than pregnancy with other diseases group,and their difference had statistical significance(P<0.05).Both groups had no statistically significant difference in thrombin time(P>0.05).Normal pregnancy group had platelet count as(155.6±47.6)×109/L,which was obviously higher than(142.7±45.8)×109/L in pregnancy with other diseases group,and the difference had statistical significance(P<0.05).Conclusion Detection of four items of blood coagulation,D-dimer and platelet detection before delivery can determine the maternal coagulation function,and it can guide the diagnosis and treatment of prenatal and postpartum hemorrhage.It also has important guiding significance in prevention of diffuse intravascular coagulation(DIC)and thromboembolic disease.

关 键 词：产妇 凝血四项 D-二聚体 血小板计数 

分 类 号：R714[医药卫生—妇产科学]