强志消迫散联合舍曲林治疗儿童强迫症的临床观察  

Clinical observation on treating child obsessive compulsive disorder with Qiangzhi Xiaopo San plus sertraline hydrochloride

作　　者：赵兴友[1] 阎兆君[2] 袁红豆 周旭[1] 

机构地区：[1]山东中医药大学,山东济南250355 [2]山东中医药大学附属医院,山东济南250014 [3]济南军区总医院,山东济南250031

出　　处：《中医临床研究》2017年第21期1-3,7,共4页Clinical Journal Of Chinese Medicine

基　　金：济南市科技局临床医学科技创新计划201602181;山东省科技发展计划2009GG20002048

摘　　要：目的:探讨强志消迫散联合舍曲林治疗儿童强迫症的疗效和安全性。方法:将符合纳入标准的60例患儿随机分为治疗组和对照组各30例,两组患儿均先经过2周药物清洗后开始治疗,治疗组予强志消迫散汤剂联合舍曲林口服,对照组予舍曲林口服治疗,共治疗12周。分别于治疗前、治疗第4周、8周、12周后采用耶鲁-布朗强迫症量表(Y-BOCS)、汉密尔顿抑郁量表(HAMD)、简明精神病量表(BPRS)、副反应量表(TESS)评定临床疗效和不良反应。比较两组治疗前后总疗效、量表积分、不良反应和安全性。结果:(1)治疗组临床治愈率为43.33%(13/30),总有效率96.67%(29/30);对照组临床治愈率为23.33%(7/30),总有效率76.67%(23/30),两组在临床治愈率与总有效率比较差异均有统计学意义(P<0.05)。(2)两组患者在治疗第4周、8周、12周Y-BOCS评分总分与治疗前比较差异均有统计学意义(P<0.05或P<0.01);治疗组治疗第8周、12周Y-BOCS评分总分与对照组比较差异均有统计学意义(P<0.05或P<0.01)。(3)两组治疗第12周Y-BOCS强迫思维分量表和强迫行为分量表、HAMD、BPRS量表评分与治疗前比较差异均有统计学意义(P<0.01);两组治疗第12周Y-BOCS强迫思维分量表和强迫行为分量表评分差异均有统计学意义(P<0.05),而HAMD、BPRS评分差异无统计学意义(P>0.05)。(4)两组间不良反应发生率、治疗前后TESS评分比较差异无显著性(P>0.05)。结论:强志消迫散联合舍曲林治疗儿童强迫症是安全有效的。Objective:To investigate the safety and efficacy of Qiangzhi Xiaopo San combined with sertraline hydrochloride on children with obsessive compulsive disorder.Methods:Sixty children were randomly divided into the treatment group and the control group,with30cases in each group.The two groups of patients were treated2weeks after the drug cleaning period.The therapy group was treated with Qiangzhi Xiaopo San combined with sertraline hydrochloride,while the control group received sertraline hydrochloride for12weeks.Yale-Brown Obsessive-compulsive Disorder Scale,Hamilton Depression Scale,Simple Psychopathology Scale and Side Effects Scale were measured before and4weeks,8weeks and12weeks after treatment to assess the clinical efficacy and adverse reactions.The total efficacy,scale points,adverse reactions and safety of two groups before and after treatment were compared.Results:1.The clinical cure rate was43.33%(13/30)in the treatment group and the total effective rate was96.67%(29/30).The clinical cure rate was23.33%(7/30)in the control group and the total effective rate was76.67%(23/30).There was a significant difference between the two groups in clinical cure rate and total effective rate(P<0.05).2.The difference of Yale-Brown Obsessive-compulsive Disorder Scale(Y-BOCS)4weeks,8weeks and12weeks after treatment and that between the two groups was statistically significant(P<0.05or P<0.01).3.The difference of Yale-Brown Obsessive-compulsive Disorder Scale,Hamilton Depression Scale and Simple Psychopathology Scale before treatment and the12th week after treatment was statistically significant(P<0.01),but there was no significant difference between HAMD and BPRS scores(P>0.05).4.There was no significant difference in the incidence of adverse reactions and TESS between the two groups(P>0.05).Conclusion:Qiangzhi Xiaopo San combined with sertraline hydrochloride was safe and effective in treating obsessive-compulsive disorder in children.

关 键 词：强志消迫散 舍曲林 儿童 强迫症 

分 类 号：R24[医药卫生—中医临床基础]