单核细胞/高密度脂蛋白比值与行急诊PCI的STEMI患者院内主要不良心血管事件的相关分析  

Correlation between monocyte-high-density lipoprotein ratio and major adverse cardiovascular events in patients with STEMI undergone emergency PCI

作　　者：于永福[1] 王岚峰[1] Yu Yongfu;Wang Lanfeng(Department of Cardiovascular Diseases, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China)

机构地区：[1]哈尔滨医科大学附属第一医院心血管内科,哈尔滨150001

出　　处：《中国循证心血管医学杂志》2017年第8期963-965,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探讨单核细胞/高密度脂蛋白比值(MHR)与行急诊经皮冠状动脉介入治疗(PCI)的急性ST段抬高型心肌梗死(STEMI)患者院内主要不良心血管事件(MACE)发生风险的关系。方法入选2015年10月~2016年6月于哈尔滨医科大学附属第一医院CCU病房行急诊PCI的286例STEMI患者,其中男性193例,女性93例,年龄40~80岁。根据住院1周内是否发生MACE将患者分为MACE组(131例)和非MACE组(155例)。由心血管介入医师行急诊冠状动脉造影检查,并行PCI。入院时测定总胆固醇、三酰甘油、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、C反应蛋白、肌酸激酶同工酶(CK-MB)、MHR、左室射血分数等。结果与非MACE组比较,MACE组左室射血分数降低,CK-MB和MHR升高,差异有统计学意义(P均<0.05)。多因素Logistic回归分析,结果显示C反应蛋白(OR=1.009,95%CI:1.001~1.016)、左室射血分数(OR=0.934,95%CI:0.905~0.963)、CK-MB(OR=1.003,95%CI:1.001~1.004)是STEMI患者院内发生MACE的影响因素。MHR升高是STEMI患者院内发生MACE的危险因素。结论 MHR与行急诊PCI的STEMI患者发生主要不良心血管事件有关,MHR越大,主要不良心血管事件发生的风险越高。Objective To discuss the relationship between monocyte-high-density lipoprotein ratio(MHR)and in-hospital major adverse cardiovascular events(MACE)in patients with ST-segment elevation myocardial infarction(STEMI)undergone emergency percutaneous coronary intervention(PCI).Methods STEMI patients undergone emergency PCI(n=286,male193,female93and aged from40to80)were chosen from the CCU of the First Affiliated Hospital of Harbin Medical University from Oct.2015to June2016.All patients were divided,according to onset of MACAE within one week after hospitalization,into MACE group(n=131)and non-MACE group(n=155).The levels of total cholesterol(TC),triglyceride(TG),high-density lipoprotein-cholesterol(HDL-C),low-density lipoprotein-cholesterol(LDL-C),C-reactive protein(CRP),creatine kinase-MB isoenzyme(CK-MB),MHR and left ventricular ejection fraction(LVEF)were detected when patients were hospitalized.Results LVEF decreased,and CK-MB and MHR increased in MACE group compared with non-MACE group(all P<0.05).The results of multi-factor Logistic regression analysis showed that CRP(OR=1.009,95%CI:1.001~1.016),LVEF(OR=0.934,95%CI:0.905~0.963)and CK-MB(OR=1.003,95%CI:1.001~1.004)were influence factors of inhospital MACE in STEMI patients.The increase of MHR was a risk factor of in-hospital MACE in STEMI patients.Conclusion MHR is correlated to MACE in STEMI patients undergone PCI,and the more the MHR is,the higher the risk of MACE is.

关 键 词：单核细胞/高密度脂蛋白比值 STEMI 主要不良心血管事件 

分 类 号：R541.4[医药卫生—心血管疾病]