Nanospike surface-modified bionic porous titanium implant and in vitro osteogenic performance  

纳米针状表面改性的仿生多孔钛植入体及体外成骨性能（英文）

作　　者：Guo-hui WANG Hua FU Ke-chao ZHOU Yan-zhong ZHAO Shai-hong ZHU 王国慧;付华;周科朝;赵颜忠;朱晒红(中南大学湘雅三医院,长沙410013;中南大学粉末冶金国家重点实验室,长沙410083)

机构地区：[1]Third Xiangya Hospital of Central South University, Central South University, Changsha 410013, China [2]State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China

出　　处：《Transactions of Nonferrous Metals Society of China》2017年第8期1815-1821,共7页中国有色金属学报（英文版）

基　　金：Projects(51290295,51305464) supported by the National Natural Science Foundation of China;Project(2016JJ6156) supported by the Natural Science Foundation of Hunan Province,China;Project(2016JC2064) supported by the Key Research and Development Program of Hunan Province,China;Project(20130162120094) supported by the Specialized Research Fund for the Doctoral Program of Higher Education,China

摘　　要：This work aimed to prepare the nanospike surface-modified bionic porous titanium implants that feature favorableosteointegration performance and anti-bacterial functions.The implant was prepared using freeze casting,and nanospikesurface-modification of the implant was performed using thermal oxidation.The pore morphology and size,mechanical properties,and osteogenic performance of the implants were analyzed and discussed.The results showed that when the volume ratio of titaniumpowder in slurry was set to be10%,the porosity,pore diameter,compressive strength,and elastic modulus of the porous sampleswere(58.32±1.08)%,(126.17±18.64)μm,(58.51±20.38)MPa and(1.70±0.52)GPa,respectively.When the porous sample wassintered at a temperature of1200°C for1h,these values were(58.24±1.50)%,(124.16±13.64)μm,(54.77±27.55)MPa and(1.63±0.30)GPa,respectively.The nanospike surface-modified bionic porous titanium implants had favorable pore morphology andsize,mechanical properties and osteointegration performance through technology optimization,and showed significant clinicalapplication prospect.通过冷冻铸造和热氧化法制备一种新型兼具抗菌功能和良好骨整合性能的纳米针状表面改性仿生多孔钛植入体。分析和表征仿生多孔钛植入体的孔隙形貌和尺寸、力学性能和体外成骨性能。结果表明:当控制冷冻铸造工艺中浆料中钛粉体积比为10%时,多孔试样的孔隙度为(58.32±1.08)%、孔径为(126.17±18.64)μm、压缩强度为(58.51±20.38)MPa、弹性模量为(1.70±0.52)GPa。在1200°C烧结1 h,多孔试样的孔隙度为(58.24±1.50)%、孔径为(124.16±13.64)μm、压缩强度为(54.77±27.55)MPa、弹性模量为(1.63±0.30)GPa。通过热氧化方法在多孔钛植入体试样的孔隙表面制备出均匀分布的纳米针状结构。通过对工艺的优化,制备出具有良好孔隙形貌和尺寸,同时具备良好力学性能和体外成骨性能的纳米针状表面改性仿生多孔钛植入体,具有重要的临床应用前景。

关 键 词：nanospike surface-modification bionic porous titanium osteogenic performance freeze casting thermal oxidation 

分 类 号：R318.08[医药卫生—生物医学工程] TG292[医药卫生—基础医学]