获得性免疫缺陷综合征相关型卡波西肉瘤口腔病损的临床特点  

Clinical characteristics of acquired immune deficiency syndrome related oral Kaposi's sarcoma

作　　者：付茜[1] 肖江 周新刚[3] 赵红心 王凌航 Fu Qian;Xiao Jiang;Zhou Xingang;Zhao Hongxin;Wang Linghang(Department of Stomatology, Beijing Ditan Hospital,Capital Medical University, 100015 Beijing, China;National Clinical Key Department of Infectious Diseases, Beijing Ditan Hospital,Capital Medical University, 100015 Beijing, China;Department of Pathology, Beijing Ditan Hospital,Capital Medical University, 100015 Beijing, China)

机构地区：[1]首都医科大学附属北京地坛医院口腔科,北京100015 [2]首都医科大学附属北京地坛医院感染病科国家临床重点专科,北京100015 [3]首都医科大学附属北京地坛医院病理科,北京100015

出　　处：《中华实验和临床感染病杂志（电子版）》2017年第4期359-363,共5页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：感染病科国家临床重点专科建设项目

摘　　要：目的总结获得性免疫缺陷综合征(AIDS)相关型卡波西肉瘤口腔病损的临床及治疗转归。方法选取首都医科大学附属北京地坛医院感染科2014年3月至2015年12月收治的7例AIDS合并卡波西肉瘤的患者资料,对其临床特征、治疗及转归进行回顾性分析。结果 7例患者均为男性、汉族,平均年龄为(37±14)岁,CD4+T细胞计数范围为10~111个/μl。7例患者均有口腔病损,其中3例仅有口腔病损,4例同时伴皮肤病损,2例合并肺部受累。口腔损害部位仅1处患者3例,多处损害者4例,累及腭部者7例,累及牙龈者2例,累及舌者1例,累及唇者1例。7例患者中3例病情好转,其中2例单用高效抗逆转录病毒(HAART)治疗,1例患者应用HAART联合全身化疗,1例患者放弃化疗,自行出院。3例患者因卡波西肉瘤(KS)播散至肺部或合并有多发的机会性感染死亡。结论 AIDS相关型卡波西肉瘤临床多见于中青年男性,口腔病损可为首发症状,常伴皮肤损害或累及内脏,治疗方案根据病损范围选择高效抗逆转入病毒治疗或高效抗逆转入病毒治疗联合系统化疗为主。Objective To investigate the clinical characteristics and prognosis of patients with acquired immune deficiency syndrome(AIDS)related oral Kaposi's sarcoma(KS).Methods The clinical characteristics,therapeutic responses and prognosis of7cases with AIDS-related oral Kaposi's sarcoma admitted in Beijing Ditan Hospital,Capital Medical University from March2014to December2015were analyzed,retrospectively.Results Total of the7cases were male and Han nationality,with the median age was(37±14)years old,counts of CD4+T cell were10-111cells/μl.All of7patients had oral lesions,among whom3cases with only manifested oral lesions,4cases with skin lesions,and another2cases with pulmonary lesions.Three cases had only one oral lesion,4cases had more oral lesions,including palate(7cases),gingival(2cases),tongue(1case)and lip(1case).There were3patients got better prognosis after receiving treatment,among whom,2patients received highly active antiretroviral therapy(HAART),1patient received HAART combined with systemic chemotherapy.Another4patients got worse prognosis,among whom1patient was gave up chemotherapy due to unaffordable further treatment,another3patients died due to KS metastasis or multiple opportunistic infections.Conclusions AIDS-related Kaposi's sarcoma occurs usually among young man,oral lesions could be the first symptoms,often with skin lesions or involvement of internal organs,the treatment options according to the size of the damage to choose HAART or HAART combined chemotherapy.

关 键 词：获得性免疫缺陷综合征 卡波西肉瘤 口腔 临床特点 

分 类 号：R512.91[医药卫生—内科学]