以梗阻性黄疸、抽搐为表现的播散性隐球菌感染1例报告  

Disseminated cryptococcosis characterized by obstructive jaundice and convulsions: a case report

作　　者：樊志文[1] 赵玲玲[1] 戴红梅[1] FAN Zhiwen;ZHAO Lingling;DAI Hongmei(Department of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha 410013, China)

机构地区：[1]中南大学湘雅三医院儿科,湖南长沙410013

出　　处：《临床儿科杂志》2017年第10期744-746,共3页Journal of Clinical Pediatrics

摘　　要：目的探讨同时累及胆道系统及中枢神经系统的播散性隐球菌病的诊断和治疗。方法回顾性分析1例同时累及胆道系统及中枢神经系统的播散性隐球菌病患儿的临床资料,同时复习相关文献。结果患儿,男,6岁。临床表现为黄疸、肝功能受损、抽搐。行手术治疗,病理活检提示隐球菌感染,血清及脑脊液隐球菌荚膜多糖抗原乳胶凝集试验阳性,脑脊液墨汁染色阳性。经抗真菌治疗后症状缓解,随访无后遗症。结论患儿为罕见的同时累积胆道、中枢系统的播散性隐球菌病。Objective To explore the diagnosis and treatment of disseminated cryptococcosis involving the biliary tract and the central nervous system.Methods The clinical data of one child with disseminated cryptococcosis involving biliary tract and central nervous system were analyzed retrospectively.The related literatures were reviewed.Results A6-year-old boy presented with jaundice,hepatic dysfunction and convulsions.The surgical treatment was performed.The pathological biopsy showed cryptococcal infection,cryptococcal capsular polysaccharide antigen latex agglutination test in serum and cerebrospinal fluid were positive and cerebrospinal fluid ink staining was also positive.After antifungal treatment,the symptoms were relieved and no sequelae existed during the follow-up period.Conclusion Disseminated cryptococcosis simultaneously involving the biliary tract and the central nervous system is rare in children.

关 键 词：胆道隐球菌病 隐球菌脑膜炎 梗阻性黄疸 

分 类 号：R725.1[医药卫生—儿科]