右美托咪定对胸腔镜下肺癌根治术患者炎症因子的影响  

Effect of Dexmedetomidine on inflammatory mediators in thoracoscopic radical resection of lung cancer

作　　者：陈顺富[1] 陈雷[1] 叶钢[1] Shun-fu Chen;Lei Chen;Gang Ye(Department of Anesthesiology, the People’s Hospital, Shaoxing, Zhejiang 312000, China)

机构地区：[1]浙江省绍兴市人民医院麻醉科,浙江绍兴312000

出　　处：《中国内镜杂志》2017年第10期72-75,共4页China Journal of Endoscopy

摘　　要：目的探讨右美托咪定对胸腔镜下肺癌根治术患者炎症因子的影响。方法选择美国麻醉医师协会(ASA)分级为Ⅰ或Ⅱ级的胸腔镜下肺癌根治术患者120例,随机分为右美托咪定组(Ⅰ组)与对照组(Ⅱ组),每组60例。并分别在麻醉诱导前(T_0)、术毕即刻(T_1)、术后12 h(T_2)、24 h(T_3)抽取外周血测定白细胞介素-8(IL-8)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的水平。结果两组患者术后T_1和T_2外周血IL-8、IL-6和TNF-α比T_0升高,Ⅰ组术后IL-8、IL-6和TNF-α明显低于Ⅱ组(P<0.05)。结论右美托咪定能减少胸腔镜下肺癌根治术患者围术期血清炎症因子IL-8和IL-6、TNF-α的水平,对抑制手术引起的过度炎症反应有一定意义。Objective To investigate the effects of Dexmedetomidine on inflammatory mediators in thoracoscopic radical resection of lung cancer.Methods120thoracoscopic radical resection of lung cancer patients ASAⅠorⅡunderwent selective operation were randomly divided into two groups:Dexmedetomidine anesthesia(groupⅠ)and control group(groupⅡ),60cases in each.In either group,peripheral venous blood was collected at the following time points:before anesthesia induction(T0),the end of the operation(T1),12h(T2)and24h(T3)after operation,and the serum concentration of IL-8,IL-6and TNF-αwere measured.Results The concentration of IL-8,IL-6and TNF-αat T1,T2were higher than that at T0,and the levels of IL-8,IL-6and TNF-αin groupⅠlower than that in groupⅡ(P<0.05).Conclusion Dexmedetomidine can decrease the level of TNF-α,IL-6and IL-8in serum of patients thoracoscopic radical resection of lung cancer.This may inhibit excessive inflammation response of patients.

关 键 词：右美托咪定 单肺通气 炎症因子 

分 类 号：R619[医药卫生—外科学]