MicroRNAs与脊髓损伤的研究进展  

Advance of microRNAs for Spine Cord Injury(review)

作　　者：张政佩 余铃[1] 孙祥然 郭卫春[1] ZHANG Zheng-pei;YU Ling;SUN Xiang-ran;GUO Wei-chun(Department of Orthopedics, Renmin Hospital ofWuhan University,Wuhan, Hubei 430060, China)

机构地区：[1]武汉大学人民医院骨I科,湖北武汉市430060

出　　处：《中国康复理论与实践》2017年第10期1152-1156,共5页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家自然科学基金项目(No.81502575);中央高校基本科研业务费专项资金项目(No.2042015kf0069)

摘　　要：脊髓损伤是一种严重的中枢神经系统性创伤,导致损伤节段以下运动和感觉功能障碍。治疗脊髓损伤的方法主要围绕恢复继发性损伤和促进再生来开展。micro RNAs(miRNAs)在脊髓损伤所导致的继发性损伤和促进再生中扮演着重要角色。本文进一步的阐述不同亚型miRNA在脊髓损伤中所起的作用,同时评价这些miRNA作为脊髓损伤治疗靶点的研究前景。Spine cord injury is a kind of severe central nervous system trauma causing motion and sensation dysfunction.Treatment focuseson controlling secondary injury cascade and improving regeneration which are heavily regulated by microRNAs(miRNAs).This reviewdiscussed the effect of miRNAs with different subtypes on spine cord injury,and investigated their potential roles as therapeutic agentsin the personalized treatment of patients with spine cord injury.

关 键 词：MICRORNA 脊髓损伤 诊断 治疗 预后 综述 

分 类 号：R651.2[医药卫生—外科学]