FRAX对老年骨质疏松性脊柱骨折的预测诊断价值分析  

The analysis on the value of FRAX in predictive diagnosis of spinal fracture for elderly patients with osteoporosis

作　　者：陈肖[1] 温清波[1] 陈浩雄[1] 王彬[1] CHEN Xiao;WEN Qing-bo;CHEN Hao-xiong;WANG Bin(Department of TCM Orthopedics & Traumatology,Shenzhen Hospital of Guangzhou University of Chinese Medicine,Shenzhen 518034, Guangdong,China)

机构地区：[1]广州中医药大学深圳医院中医骨伤科,广东深圳518034

出　　处：《川北医学院学报》2017年第4期498-500,共3页Journal of North Sichuan Medical College

基　　金：福田区卫生公益性课题(FTWS20160036)

摘　　要：目的:分析骨质疏松性骨折风险预测简易工具(fracture risk assessment tool,FRAX)对老年骨质疏松性脊柱骨折发生的预测诊断价值。方法:分析在本院接受诊疗的96例老年骨质疏松患者的临床资料,依据是否合并骨质疏松性脊柱骨折将患者分为观察组(骨折,n=45)及对照组(未骨折,n=51)。每位患者均行FRAX及骨质疏松自我筛查工具(osteoporosis self-assessment tool for asians,OSTA)评估,并接受骨密度测量。结果:观察组患者FRAX指数显著高于对照组患者,而OSTA指数及骨密度值均显著低于对照组患者,各项差异均具有统计学意义(P<0.05)。ROC曲线分析显示,以3.92为截点值,FRAX指数预测诊断老年骨质疏松性脊柱骨折的敏感性为92.16%,特异性为84.44%,曲线下面积为0.94,优于OSTA指数。相关性分析显示观察组患者FRAX指数与骨密度值呈现显著负相关,具有统计学意义(r=-0.538,P<0.01)。结论:FRAX在预测老年骨质疏松患者脊柱骨折发生中具有一定价值,该工具具有临床推广价值。Objective:To analyze the value of fracture risk assessment tool(FRAX)in predictive diagnosis of spinal fracture for elderly patients with osteoporosis.Methods:Clinical data of96patients with osteoporosis received treatment in our hospital were ana-lyzed.Patients were divided into observation group(fracture,n,=45)and control group(not fracture,?!=51)by whether suffered from spinal fracture.All patients were treated with FRAX and osteoporosis self-assessment tool for asians(OSTA),and received the test of bone density measurement.Results:Patients in the observation group had higher FRAX score,but lower OSTA score and bone density value than these in the patients of the control group,the differences were statistically significant(P<0.05).ROC analysis showed that the FRAX score index(cut-off point value of3.92)was used for predictive diagnosis of spinal fracture for elderly patients with osteopo-rosis,and provided a sensitivity of92.16%,a specificity of84.44%,area under the curve of0.94,were better than these of OSTA.Correlation analysis showed that the levels of bone density value in the patients of the observation group had significant negative correla-tion with FRAX score(r=-0.538,P<0.01),which was statistically significant.Conclusion:In predictive diagnosis of spinal frac-ture for elderly patients with osteoporosis,the FRAX is valuable,be worthy of clinical expansion.

关 键 词：FRAX 老年 骨质疏松症 脊柱骨折 诊断 

分 类 号：R580[医药卫生—内分泌] R683[医药卫生—内科学]