IMA和H-FABP在心源性猝死法医学诊断中的应用  

Application of IMA and H-FABP in Forensic Diagnosis of Sudden Cardiac Death

作　　者：朱泽磊[1,2] 王鹏 尤家斌[1] 岳强 王鹏飞 王晓龙 张楚楠[1] 张国华 ZHU Ze-lei;WANG Peng;YOU Jia-hin;YUE Qiang;WANG Peng-fei;WANG Xiao-long;ZHANG Chu-nan;ZHANG Guo-hua(School of Forensic Medicine, China Medical University, Shenyang 110001, China;Criminal Investigation Detachment, Shijingshan Branch of Beijing Public Security Bureau, Beijing 100043, China;Criminal Police Detachment, Tieling Public Security Bureau, Tieling 112000, China)

机构地区：[1]中国医科大学法医学院,辽宁沈阳110001 [2]北京市公安局石景山分局刑侦支队,北京100043 [3]铁岭市公安局刑警支队,辽宁铁岭112000

出　　处：《法医学杂志》2017年第4期393-396,共4页Journal of Forensic Medicine

基　　金：公安部应用创新计划资助项目(2009YYCXLNST021)

摘　　要：急性心肌缺血的发生是心源性猝死的最常见原因,而如何认定早期急性心肌缺血是法医学研究的热点,同时也是临床预防心肌梗死发生的重要环节。本文通过对缺血修饰白蛋白(ischemia modified albumin,IMA)和心型脂肪酸结合蛋白(heart-type fatty acid binding protein,H-FABP)的结构、功能、临床应用价值及法医学中的应用前景进行综述,旨在分析二者是否可作为早期心肌缺血的生化检测指标用于心源性猝死的诊断,并为今后选择心源性猝死的科研方向提供借鉴。Acute myocardial ischemia is the most common cause of sudden cardiac death.The diagnosis of early myocardial ischemia is a hot point in forensic medicine,which is also an early and important part for a prevention against myocardial infarction.This paper conducts a comprehensive discussion of the structure,function,clinical value and forensic medicine application prospect of ischemia modified albumin(IMA)and heart-type fatty acid binding protein(H-FABP),aiming to determine whether the two proteins can be used as biochemical detection indicators of early myocardial ischemia for the diagnosis of sudden cardiac death in forensic medicine.

关 键 词：法医病理学 猝死 心源性 综述 缺血修饰白蛋白 心型脂肪酸结合蛋白 心肌缺血 

分 类 号：DF795.1[医药卫生—法医学]