转录因子7类似物2基因的rs7903146位点多态性与新疆维吾尔族人群2型糖尿病的相关性研究  

Association of rs7903146 polymorphisms in TCF7L2 gene with type 2 diabetes mellitus in Uygur population of Xinjiang

作　　者：王志强[1,2] 李豫凯[1] 朱筠[3] 马琦[2] 苏银霞[2] 王黎[2] 陈志远 刘莉娜[3] 姚华[2] WANG Zhi-qiang;LI Yu-kai;ZHU Jun;MA Qi;SU Yin-xia;WANG Li;CHEN Zhi-yuan;LIU Li-na;YAO Hua(Department of Public Health, Xinjiang Medical University, Urumqi 830011, China;The Key Laboratory o f Metabolic Disease Research,The First Affiliated Hospital o f Xinjiang Medical University,Urumqi 830054, China;Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054, China)

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830011 [2]新疆医科大学第一附属医院代谢性疾病重点实验室,新疆乌鲁木齐830054 [3]新疆医科大学第一附属医院内分泌科,新疆乌鲁木齐830054

出　　处：《中国病理生理杂志》2017年第8期1443-1448,共6页Chinese Journal of Pathophysiology

基　　金：国家重点基础研究发展计划(973计划)(No.2012CB722403)

摘　　要：目的:探讨新疆地区维吾尔族人群转录因子7类似物2(transcription factor 7-like 2,TCF7L2)基因的rs7903146位点多态性与2型糖尿病的相关性。方法:采用病例-对照研究方法,以经确诊的935例2型糖尿病患者作为2型糖尿病组,选取971例健康体检者作为正常对照组。应用基质辅助激光解吸电离飞行时间质谱分析技术对TCF7L2基因多态性进行检测。结果:rs7903146位点基因型CC、CT和TT以及等位基因C和T在2型糖尿病组与正常对照组中分布的差异具有统计学意义(P<0.05)。T等位基因携带者患2型糖尿病的风险是C等位基因携带者的1.190倍(OR=1.190,95%CI为1.034~1.371),CT基因型携带者患2型糖尿病的风险是CC基因型携带者的1.374倍(OR=1.374,95%CI为1.122~1.683),CT+TT基因型携带者患2型糖尿病的风险是CC基因型携带者的1.307倍(OR=1.307,95%CI为1.090~1.567)。在全体人群中,rs7903146位点的CT+TT基因型携带者的空腹血糖、肌酐和尿素氮水平显著高于CC基因型携带者,差异均具有统计学意义(P<0.05)。结论:TCF7L2基因的rs7903146位点可能与新疆维吾尔族人群2型糖尿病的发生相关,T等位基因和CT基因型可能是2型糖尿病发生的危险因素。AIM:To investigate whether rs7903146polymorphisms in transcription factor7like2(TCF7L2)gene are associated with susceptibility to type2diabetes mellitus(T2DM)in Chinese Uygur population.METHODS:In this casecontrol study,935cases of T2DM patients were recruited in T2DM group,and971healthy examination individuals were selected as normal control.TheTCF7L2gene polymorphism was detected by matrixassisted laser desorption/ionization timeofflight mass spectrum.RESULTS:Significant differences in the frequencies of CC,CT and TT genotypes and the frequencies of C and T alleles onTCF7L2rs7903146were found between T2DM group and control group(P<0.05).As compared with C allele,the patients with T allele had a significantly higher risk of T2DM withORof1.190(95%CI:1.034~1.371)As compared with CC genotype,the patients with CT genotype had a significantly higher risk of T2DM withORof1.374(95%CI:1.122~1.683),and the patients with CT+TT genotype had a significantly higher risk of T2DM withORof1.307(95%CI:1.090~1.567).The levels of fasting plasma glucose,serum creatinine and bloodureanitrogen were higher in all participants with CT+TT genotype of rs7903146than those with CC genotype,which showed a significant difference(P<0.05).CONCLUSION:The polymorphisms of rs7903146inTCF7L2ene may be associated with T2DM in Uygur population from Xinjiang region.The T allele and CT genotype of rs7903146are the risk factors for T2DM.

关 键 词：单核苷酸多态性 转录因子7类似物2基因 2型糖尿病 维吾尔族 

分 类 号：R587.1[医药卫生—内分泌] R394.5[医药卫生—内科学]