维生素D与生殖功能的关系及其研究进展  

The progress study on the relationship between vitamin D and human reproductive function

作　　者：刘婷婷[1] 魏子恒 李文[1] LIU Ting-ting;WEI Zi-heng;LI Wen(Department of Reproductive Medical Center, Changzheng Hospital,Second Military Medical University, Shanghai 200003, China)

机构地区：[1]第二军医大学长征医院生殖医学中心,上海200003

出　　处：《中国医学前沿杂志（电子版）》2017年第8期23-28,共6页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：上海市科委医学引导项目(1641963500);上海市科委标准项目(16DZ0500402);军事医学创新工程(16JS007)

摘　　要：既往研究表明维生素D的生理功能为参与骨质代谢和促进骨质生长。近年来,越来越多研究表明,维生素D受体不仅存在于骨、肝脏及肾脏中,其在男性睾丸、精子和女性卵巢、子宫等生殖器官、组织及细胞中也有广泛表达。缺乏维生素D不仅会引起生殖相关疾病发病率的增加,还会影响精子和卵泡质量,从而导致不孕不育。本文主要对维生素D与生殖功能的关系进行综述,以期对应用维生素D预防和辅助治疗不孕不育这一新思路进行探索。Previous studies have suggested that the physiological functions of vitamin D are participating in bone metabolic regulation and promoting bone growth.Currently,a growing number of researches indicates that vitamin D receptors(VDR)mainly exist in bone,liver and kidney.Besides,they can also be found in some reproductive organs,tissues and cells,such as testis,sperm of male,and ovary,uterus of female.Deficiency of vitamin D will not only increase the incidence of reproductive related diseases,but also affect the quality of sperm and follicles,which can lead to infertility.In order to further explore the new idea that applying vitamin D to the prevention and adjuvant therapy of sterility infertility,this paper reviews researches on the relationship between vitamin D and human reproductive function.

关 键 词：维生素D 生殖功能 维生素D受体 

分 类 号：R711.6[医药卫生—妇产科学]