一起伤害案中的先天性嵌合体法医学分析  

Forensic Analysis of Genetic Chimera from an Injury Case

作　　者：王祥[1] 黄雯[2] 李上勋[1] 王锟[1] 张毅 彭皓明[1] WANG Xiang;HUANG Wen;LI Shangxun;WANG Kun;ZHANG Yi;PENG Haoming(Hubei Provincial Public Security Department, Wuhan 430070, China;Wuchang Sub-bureau of Wuhan Public Security Bureau, Wuhan 430060, China)

机构地区：[1]湖北省公安厅,武汉430070 [2]武汉市公安局武昌分局,武汉430060

出　　处：《刑事技术》2017年第5期422-424,共3页Forensic Science and Technology

摘　　要：本文通过对1例伤害案发现的女性嵌合体及部分家族成员进行常染色体STR遗传分析,探讨先天性嵌合体发生、组织表现及法医学鉴定的要点。该嵌合体为胚胎早期女性-男性的异卵双生子发生融合发育而成,随生长逐渐遍布至全身组织器官。由于细胞系分布不均,先天性嵌合体不同组织可呈现不同的STR基因型,一些STR基因座还会出现多等位基因嵌合现象,因此采集亲属、多组织器官检材进行DNA分析很重要,可防止法医鉴定误判的发生。A female genetic chimera was found from an injury case,resulting in the investigation on its development,histological exhibition and key points of forensic inspection.The autosomal STR analyses were performed to the femalechimera and her family members,leaving a discovery of her whole body’s chimera of the female.Thus,it can be presumedthat a mixis had occurred and then developed from a female-male heterozygotic zygote during that female’s pre-embryonicperiod.Accordingly,disparate STR typing and multi-allelic chimerism in certain STR locus were detected in different tissuesamples due to the unbalanced distribution of two sexual cell lines.It is suggested that detection should be made on moretissue samples of both a chimera and the relevant family members so as to prevent from misjudgement in forensic expertise.

关 键 词：嵌合体 STR分型 法医遗传学 

分 类 号：DF795.2[医药卫生—法医学]