口服Gd-DTPA稀释液在2D-MRCP检查中的体内外实验  

In vitro/in vivo Experiments of Oral Gd-DTPA Dilution in 2D-MRCP Examination

作　　者：张磊[1] 杨亚英[2] 杨兑明 姜启树 吴艳艳[1] 高敏[1] 赵珍[3] ZHANG Lei;YANG Ya-ying;YANG Dui-ming;JIANG Qi-shu;WU Yan-yan;GAO Min;ZHAO Zhen(Dept. of Imaging,The Second People’s Hospital of Baoshan City, Baoshan Yunnan 678000;Department of Imaging,The First Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032;Kunming Medical University,Kunming Yunnan 650500,China)

机构地区：[1]保山市第二人民医院影像科,云南保山678000 [2]昆明医科大学第一附属医院影像中心,云南昆明650032 [3]昆明医科大学,云南昆明650500

出　　处：《昆明医科大学学报》2017年第10期79-82,共4页Journal of Kunming Medical University

基　　金：云南省卫生科技计划项目(2014NS158)

摘　　要：目的通过体外、体内实验研究,筛选出2D-MRCP检查时口服Gd-DTPA稀释液作为胃肠道阴性对比剂的最佳浓度、容量及扫描时间.方法 (1)体外研究:取静脉用Gd-DTPA注射液0.05、0.10、0.15和0.20m L,稀释成浓度分别为0.25、0.50、0.75、1.00 mmol/L的溶液各100 m L;另备100 m L温开水作为对照组,行2D-MRCP序列扫描,测量不同浓度对比剂的信号强度及衰减率.(2)体内研究:选取体外实验中显示最佳信号强度及衰减率的Gd-DTPA稀释液作为胃肠道阴性对比剂,配制成50 m L及100 m L二种容量,分别给2组患者口服后4~6 min、9~11 min行2D-MRCP扫描,观察胃及十二指肠内高信号液体的抑制情况及患者服用对比剂后有无不良反应.结果 (1)在口服浓度为1.00 mmol/L、容量为100 m L的Gd-DTPA稀释液后9~11 min行2D-MRCP扫描,可完全抑制胃及十二指肠内高信号液体;(2)口服Gd-DTPA稀释液配制简便,口服量少,服用后患者无任何不适反应,是一种较为理想的口服胃肠道阴性对比剂.结论口服适宜浓度、容量的Gd-DTPA稀释液在合适的检查时间行2D-MRCP序列扫描,可有效抑制胃及十二指肠内液体的高信号影.Objective To select the best concentration,volume and checking time of Gd-DTPA dilution as an oral negative gastrointestinal contrast agent by in vitro/in vivo experiments.Methods(1)In vitro experiments:we used0.05,0.10,0.15and0.20mL intravenous injections of Gd-DTPA,which were diluted into concentrations of0.25,0.50,0.75,1.00mmol/L,then we examined and made a contrastive analysis about the signal intensity and attenuation rate of2D-MRCP with different concentration contrast agent.(2)In vivo experiments:we used the optimum concentration of Gd-DTPA dilution with50and100mL,made2D-MRCP scanning on20cases in two groups in4-6minutes and9-11minutes respectively after oral administration of Gd-DTPA dilution,and observed the restraint of the high signal liquid in stomach and duodenum,and whether the patients had adverse reactions.Results(1)It showed that the high signal liquid in stomach and duodenum of some patients with oral administration of100ml dilution with1.00mmol/L concentration could be fully restrained in9-11minutes.(2)The allocation of oral Gd-DTPA dilution is simple,the effect of restraining the high signal liquid in stomach and duodenumis well after oral administration of little dilution,and the patients have no adverse reactions,so it is a good oral gastrointestinal contrast agent.Conclusions2D-MRCP scanning in suitable time after oral administration of Gd-DTPA dilution with proper concentration and volume can effectively restrain the high signal liquid in stomach and duodenum.

关 键 词：磁共振胰胆管成像 钆喷酸葡胺 口服 浓度 容量 检查时间 

分 类 号：R445.2[医药卫生—影像医学与核医学]