PICU脓毒血症患者血小板计数、D-二聚体水平与小儿危重病例评分及预后相关性  

Correlation Between Platelet Count and D-two Level in Patients with PICU Septicopyemia and Pediatric Critical Illness Score PCIS and Prognosis

作　　者：王卫凯[1] 蔺茹[1] 尤银刚 徐瑞峰[1] 吴珠明[1] Wang Weikai;Lin Ru;You Yingang;Xu Ruifeng;Wu Zhuming(Gansu Provincial Maternity and Child-care Hospital,Lanzhou 730050,China;The Second People's Hospital of Lanzhou City,Lanzhou 730000,China)

机构地区：[1]甘肃省妇幼保健院,甘肃兰州730050 [2]兰州市第二人民医院,甘肃兰州730000

出　　处：《甘肃科学学报》2017年第5期78-81,共4页Journal of Gansu Sciences

摘　　要：观察PICU收治脓毒血症患者血小板计数、D-二聚体水平与小儿危重病例评分及预后的相关性。选择本院PICU2013年01月—2014年12月入住PICU临床资料完整的85例脓毒血症患者为研究对象进行回顾性分析。根据危重病例评分分值分为3组,非危重组(80<评分值<100)、危重组(70<评分值<80)和极危重组(0<评分值<70分),入PICU后抽取血样测定血小板计数、D-二聚体水平,行小儿危重病例评分,分析血小板计数、D-二聚体水平与小儿危重病例评分相关性。观察患者预后情况发现,极危重组患者血小板计数明显低于危重组患者(t=5.23,P<0.01)、非危重组患者(t=2.18,P<0.01);而极危重组患者D-二聚体水平明显高于危重组患者(t=3.46,P<0.01)、非危重组患者(t=9.58,P<0.01);极危重组患者病死率明显高于危重组患者(X2=16.45,P<0.01)、非危重组患者。死亡组患者的小儿危重病例评分分值明显低于存活组(t=3.35.P<0.05),而D-二聚体水平明显高于存活组(t=9.63,P<0.05);血小板计数明显低于存活组(t=4.23,P<0.05)。差异均有统计学意义。血小板计数、D-二聚体水平与小儿危重病例评分均显著相关。随着小儿危重病例评分下降,血小板计数相应下降,D-二聚体水平相应增高;D-二聚体水平与病情严重程度正相关,血小板计数则与病情严重程度负相关,是病情严重程度的早期、敏感、定量的指标。Correlation between platelet count and D-two levels in patients with PICU septicopyemia and critical illness score and prognosis in children was observed.85cases of sepsis patients with complete PICU clinical data stayed in the hospital PICU from January2013to December2014were selected,a retrospective analysis was performed.They were divided into3groups according to the scores of critical cases,that was non critical group(80<score<100),critical group(70<score<80)and extremely critical group((0<score<70).Blood samples were taken after PICU and platelet count and D-two levels were measured.After entering PICU,blood samples were taken to measure platelet count and D-two levels,Pediatric Critical I1--ness Score PCIS was carried out,the correlation between platelet count and D-two levels and ical Illness Score PCIS was analyzed.The prognosis of the patients was observed.Platelet count in extremely critical group patients was significantly lower than that in critical group patients t=5.23,P<0.01)and non critical group patients t=2.18,P<0.01)while the level of D-two in extremely critical group patients was significantly higher than that in critical group patients(t=3.46,P<0.01)and non critical group patients(t=9.58,P<0.01);the mortality of extremely critical group patients was significantly higher than that in critical group patients(X2=16.45,P<0.01)and non of critical group patients.The Pediatric Illness Score PCIS in the death group was significantly lower than that in the survival group(t=3.35,P<0.05),the level of D-two was significantly higher than that in the survival group(t=9.63,P<0.05);platelet count was lower than that in the survival group(t=4.23,P<0.05).The differences were statistically significant.Platelet count and D-two levels were significantly correlated with Pediatric Critical Illness Score PCIS.With the decrease of Pediatric Critical Illness Score PCIS,the platelet count decreased correspondingly,and the level of D-two increased accordingly.The level of D-two was positively related to the severity of

关 键 词：脓毒血症 血小板 D-二聚体 小儿危重病例评分 预后 

分 类 号：R459.7[医药卫生—急诊医学]