lncRNA在癌细胞生长和代谢中的作用研究进展  

Function of long non-coding RNA in cancer cell growth and metabolism

作　　者：田海华[1,2] 李静秋 杨杰[1] 龚朝辉[1] TIAN Hai-hua;LI Jing-qiu;YANG Jie;GONG Zhao-hui(Medical School, Ningbo University, Ningbo 315211, China;Ningbo Kangning Hospital, Ningbo 315201, China)

机构地区：[1]宁波大学医学院,浙江宁波315211 [2]宁波市康宁医院,浙江宁波315201

出　　处：《宁波大学学报（理工版）》2017年第6期90-97,共8页Journal of Ningbo University：Natural Science and Engineering Edition

基　　金：浙江省自然科学基金(LY15C060003);宁波市自然科学基金(2015A610220);浙江省公益技术研究计划(LGF18H160006);宁波大学王宽诚教育基金

摘　　要：从长链非编码RNA(long non-coding RNA,lncRNA)与癌细胞生长和代谢的关系角度,系统地分析和综述了lncRNA如何通过促进或抑制细胞周期进程调节癌细胞生长,lncRNA如何通过调节上皮间质转化影响癌细胞迁移,以及lncRNA在肿瘤细胞糖类和脂类代谢中如何发挥其作用.Long non-coding RNAs(lncRNAs)are widely found in human cells and involve in vital life processes of gene expression,epigenetic regulation and X-chromosome inactivation.They are suggested to be closely related to tumorigenesis and growth suppression.The review focuses on the role of lncRNA in cancer cell growth and metabolism.A growing body of evidence suggests that lncRNA regulates cancer cell growth by promoting or inhibiting cell cycle.In addition,the review includes how lncRNA affects epithelial-mesenchymal transition(EMT)-mediated cell migration,and how lncRNA functions as a regulator in the glucose and lipid metabolism in tumor cells.

关 键 词：长链非编码RNA 细胞周期 细胞迁移 肿瘤代谢 肿瘤标志物 

分 类 号：R34[医药卫生—基础医学]