补肾活血方治疗颈动脉粥样硬化斑块临床研究  

Clinical Research on Bushen Huoxue Decoction in Treating Carotid Atherosclerotic Plaque

作　　者：田琳[1] 贾莉[1] 牟秀霞[1] 王瑶[1] 吴巍[1] 朱建贵[1] TIAN Lin;JIA Li;MU Xiu-xia;WANG Yao;WU Wei;ZHU Jian-gui(Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China)

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中国中医药信息杂志》2017年第12期17-20,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(81303015);人事部留学人员科技活动择优资助项目(2013年)

摘　　要：目的观察补肾活血方治疗颈动脉粥样硬化斑块的有效性及安全性。方法纳入颈动脉粥样硬化斑块患者50例,进行健康宣教。同时予补肾活血方颗粒剂,每日1剂,每日2次,冲服。连续治疗12周。观察治疗前后颈动脉超声相关指标,观察治疗前及治疗4、8、12周中医症状评分。观察治疗前后空腹血糖(FBG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、血清C反应蛋白(CRP)、同型半胱氨酸(HCY)、白细胞介素-6(IL-6)、胰岛素样生长因子-1(IGF-1)、骨保护素(OPG)水平,监测血、尿常规及肝、肾功能。结果治疗后斑块Crouse积分、斑块等级积分较治疗前呈降低趋势,差异无统计学意义(P=0.060,P=0.336);改良斑块总积分、最大斑块面积较治疗前降低(P<0.05)。治疗第4、8、12周,中医症状积分降低(P<0.01),且随着治疗时间增加,中医症状积分显著下降(F=160.352,P<0.001)。中医疗效总有效率为85.11%(40/47)。治疗后血清FBG、TC含量较治疗前降低,差异有统计学意义(P<0.05);血清LDL-C、HCY、CRP、IL-6、IGF-1、OPG较治疗前有降低趋势,差异无统计学意义(P>0.05)。血、尿常规及肝、肾功能未见异常。结论补肾活血方治疗颈动脉粥样硬化斑块临床疗效较好,可改善患者临床症状,缩小并稳定斑块,安全性较高。Objective To investigate the efficacy and safety of Bushen Huoxue Decoction in the treatment of carotid atherosclerotic plaque.Methods Totally50patients of carotid atherosclerotic plaque were collected to conduct health education.At the same time,they were given Bushen Huoxue Decoction,one dosage a day,twice a day,decoction,for12weeks.The correlation indexes of carotid artery before and after treatment were observed,and TCM syndrome integrals were evaluated before and after4,8and12weeks treatment.FBG,TC,LDL-C,CRP HCY,IL-6,IGF-1,and OPG were detected before and after treatment.Hematuria routine,liver and renal function were monitored.Results After treatment,the Crouse score and the plaque grade score of carotid atherosclerotic plaque showed a tendency to decrease,without statistical significance(P=0.060,P=0.336).Carotid maximal plaque area and modified total score of carotid atherosclerotic plaque were significantly reduced compared with that before treatment(P<0.05).TCM syndrome integrals were significantly reduced compared with that before treatment(P<0.05),and the scores decreased significantly with the prolongation of treatment time.TCM syndrome integrals after4,8,and12weeks were significantly reduced compared with that before treatment(F=160.352,P<0.001).Total effective rate of treatment in the efficacy of TCM syndrome was85.11%(40/47).Serum levels of FBG and TC decreased significantly after the treatment compared with that before the treatment,with statistical significance(P<0.05).Serum levels of LDL-C,HCY,CRP,IL-6,IGF-1,and OPG all showed a tendency to decrease,without statistical significance(P>0.05).No abnormality in hematuria routine,liver and renal function examinations were found during the research.Conclusion Bushen Huoxue Decoction has obvious clinical efficacy for carotid atherosclerotic plaque,which can improve clinical symptoms of patients,it also could stabilize and reduce plaque with high safety.

关 键 词：补肾活血方 肾虚血瘀证 颈动脉粥样硬化斑块 

分 类 号：R255.6[医药卫生—中医内科学]