Environmentally friendly, microwave-assisted synthesis of 5-substituted 1H-tetrazoles by recyclable CuO nanoparticles via(3+2) cycloaddition of nitriles and NaN_3  

可重复使用CuO纳米粒子催化微波辅助的腈和NaN_3环加成反应合成5-取代1H-四唑类（英文）

作　　者：R. D. Padmaja Sourav Rej Kaushik Chanda R. D. Padmaja;Sourav Rej;Kaushik Chanda(韦洛尔大学高等科学学院化学系,印度韦洛尔632014;生物工程与纳米技术研究所,新加坡138669)

机构地区：[1]Department of Chemistry, School of Advanced Sciences, VIT University, Vellore‐632014, India [2]Institute of Bioengineering and Nanotechnology, A*STAR. 31 Biopolis Way, Singapore‐138669

出　　处：《Chinese Journal of Catalysis》2017年第11期1918-1924,共7页催化学报（英文）

基　　金：CSIR-Govt of India for funding through Grant No. 01(2913)/17/EMR-II

摘　　要：Recyclable CuO nanoparticles were successfully employed to catalyze the microwave‐assisted(3+2)cycloaddition reaction between nitriles and NaN3to efficiently synthesize5‐substituted1H‐tetrazoles.The salient features associated with this protocol are its cost effectiveness,rapid synthesis,stability,reusability,mild reaction conditions without any additives,high tolerance to various functional groups,and excellent yields under microwave irradiation.This environmentally friendly,microwave‐assisted,nanoparticle‐catalyzed synthetic methodology is seen as an alternative to conventional procedures that involve Lewis acid catalysts and a simple operation to the privileged scaffold.将可重复使用的CuO纳米粒子成功用于催化微波辅助的腈和NaN_3[3+2]环加成反应高效合成5-取代1H-四唑类化合物.该法突出特点为成本低、合成快、稳定性高、可重复使用、反应条件温和、无需任何添加物、官能团兼容性好和产率高.这种环境友好的微波辅助纳米粒子催化合成策略可望替代现有的涉及常规路易斯酸催化剂方法,以及作为一种简易的合成特殊化合物的方法.

关 键 词：TETRAZOLES CuO nanoparticles (3+2) cycloaddition Green chemistry Microwave irradiation 

分 类 号：O626.28[理学—有机化学]