钯催化芳基亚磺酸钠合成C-3芳基化中氮茚  

Palladium-catalyzed C-3 desulfitative arylation of indolizines with sodium aryl sulfinates

作　　者：苗潇潇 田丰收 张肖静 王运生 王春杰 MIAO Xiaoxiao;TIAN Fengshou;ZHANG Xiaojing;WANG Yunsheng;WANG Chunjie(Chemistry Department of Zhoukou Normal University,Zhoukou 466000,China)

机构地区：[1]周口师范学院化学化工学院,河南周口466000

出　　处：《周口师范学院学报》2017年第2期95-96,共2页Journal of Zhoukou Normal University

基　　金：河南省科技攻关项目(No.172102310626);河南省教育厅重点项目(No.15A150687);周口师范学院2016年度大学生科研创新基金项目(No.zknuD201697)

摘　　要：利用芳基亚磺酸钠直接合成C-3芳基化的中氮茚衍生物——3-苯基-1-氰基中氮茚.基于钯催化利用芳基亚磺酸钠合成3-苯基-1-氰基中氮茚的反应需要过氧化物的协助,而且含N配体催化效率更高.这种方法为C-3功能化中氮茚分子的合成提供新方法.This paper,derivatized indolizine-3-phenylindolizine-1-carbonitrile was efficiently prepared by direct C-3arylation of indolizines using sodium arylsulfinates.Pd-catalyzed desulfitative C-3arylation with sodium arylsulfinates was achieved with the assistance of peroxides,and the catalytic efficiency was promoted by N-containing ligands.This kind of synthesis for C-3desulfitative arylation of indolizines provides a new method.

关 键 词：芳基亚磺酸钠 钯催化 中氮茚 合成 

分 类 号：O625[理学—有机化学]