替罗非班辅助经桡动脉入径直接经皮冠状动脉介入治疗术治疗心肌梗死患者的疗效观察及对患者住院时间的影响  

Effect of tirofiban-assisted transradial approach to direct percutaneous coronary intervention on the treatment of myocardial infarction and its impact on hospitalization time

作　　者：王超[1] 李永健[1] 金喆[1] 董阳[1] WANG Chao;LI Yong-jian;JIN Zhe;DONG Yang(Department of Cardiology, Nankai Hospital, Tianjin 300100, China)

机构地区：[1]天津市南开医院心内科,天津300100

出　　处：《中国生化药物杂志》2017年第11期155-156,共2页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨替罗非班辅助经桡动脉入径直接经皮冠状动脉介入手术对心肌梗死患者的疗效及对住院时间的影响效果。方法选取天津市南开医院2014年5月～2017年5月收治的78例心肌梗死患者，利用随机数字表法分为研究组和对照组，每组39例。2组均接受经桡动脉入径直接经皮冠状动脉介入手术，对照组常规给予抗凝及抗血小板聚集药物，研究组在对照组用药基础上加用替罗非班。记录2组心肌梗死患者主要终点事件（新发心肌梗死、死亡、梗死后心绞痛等）发生情况、住院时间。结果研究组梗死后心绞痛、复合终点发生率显著低于对照组（P＜0.05）；研究组平均住院时间（21.03±1.06）d、对照组平均住院时间（26.14±1.79）d，2组差异有统计学意义（P＜0.05）。结论替罗非班辅助经桡动脉入径直接经皮冠状动脉介入治疗心肌梗死疗效显著，可有效降低患者主要终点事件发生率及缩短住院时间。Objective To investigate the effect of tirofiban-assisted transradial approach to direct percutaneous coronary intervention on the treatment of myocardial infarction and its impact on hospitalization time.Methods A total of78patients with myocardial infarction treated in Tianjin Nankai Hospital from May2014to May2017were randomly divided into study group and control group,39cases in each group.The two groups received transradial approach to direct percutaneous coronary intervention,while the control group received anticoagulant and anti platelet aggregation drugs,the study group was given tirofiban on the basis of the control group.The main outcome events(new myocardial infarction,death,post infarction angina pectoris)and hospitalization time were recorded in two groups of patients with myocardial infarction.Results The incidence of postinfarction angina pectoris and composite end point in the study group was significantly lower than that in the control group(P<0.05).The average hospitalization time of the study group was(21.03±1.06)d,the average hospitalization time of the control group was(26.14±1.79)d,the difference was statistically significant(P<0.05).Conclusion The effect of tirofiban-assisted transradial approach to direct percutaneous coronary intervention in patients with myocardial infarction is significant,which can effectively reduce the incidence of major end events and shorten hospital stay.

关 键 词：心肌梗死 桡动脉路径 经皮冠状动脉介入治疗 替罗非班 住院时间 

分 类 号：R542.22[医药卫生—心血管疾病]