小剂量瑞替普酶联合替罗非班治疗老年急性ST段抬高型心肌梗死的研究  

Low-dose reteplase combined with tirofiban in treatment of acute STsegment elevation myocardial infarction

作　　者：周世泰[1] 陈尚扣 黄仁春[1] ZHOU Shi-tai;CHEN Shang-kou;HUANG Ren-chun(Department of Emergency Medicine, Hanzhong Central Hospital, Hanzhong 723000,China)

机构地区：[1]汉中市中心医院急诊科,陕西汉中723000

出　　处：《中国生化药物杂志》2017年第12期32-33,35,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：黑龙江省教育厅科研课题(2016-KYYWF-0606)

摘　　要：目的探讨小剂量瑞替普酶联合替罗非班对老年急性ST段抬高型心肌梗死（ASTMI）影响。方法选取2013年5月～2017年5月汉中市中心医院接受治疗的202例AMI患者，依据患者意愿将其均为分2组。对照组采用常规剂量瑞替普酶溶栓治疗；观察组选择小剂量瑞替普酶实施治疗。对比2组治疗前后氧化应激反应、炎症反应及应激激素表达情况。结果经治疗，2组MCP-1明显下降，SOD活性明显激活，COR、EP及hs-CRP、TNF-α水平均明显下降，而观察组MCP-1、COR、GH、EP、hs-CRP、TNF-α明显低于对照组，SOD活性明显强于对照组（P＜0.05）。结论小剂量瑞替普酶与替罗非班合用，可有效ASTMI炎症反应程度及抑制氧化应激反应激活，阻止心肌细胞进一步损伤。Objective To investigate the effect of low-dose remitrolase combined with tirofiban on acute ST-elevation myocardial infarction(ASTMI)in elderly patients.Methods202patients from May2013to May2017were divided into two groups according to the patients’treatment intention.The control group was treated with conventional dose of reteplase for therapy.The observation group was treated with low dose reteplase for treatment.The degree of oxidative stress,inflammatory response and the expression of stress hormones were compared between the two groups before and after treatment.Results After treatment,the levels of MCP-1,COR,EP,hs-CRP and TNF-αwere significantly decreased,and the activity of SOD was significantly activated.The levels of the indexes in the observation group were significantly better than those in the control group(P<0.05).Conclusion Low dose of reteplase combined with tirofiban can effectively reduce the degree of inflammatory response of ASTMI,inhibit the activation of oxidative stress and prevent further damage of myocardial cells.

关 键 词：缺血性胸痛/药物疗法 瑞替普酶 替罗非班 

分 类 号：R64[医药卫生—外科学]