透皮给药靶向治疗对肛瘘术后患者创面愈合及肛门疼痛的影响  

Influence of transdermal drug delivery targeted therapy on wound healing and anal pain after anal fistula surgery

作　　者：周立宇[1] 罗静泳[1] 黄城鑫[1] ZHOU Li-yu;LOU Jing-yong;HUANG Chen-xin(Department of Anus & Intestine Surgery, the First People’s Hospital of Xiaoshan District, Hangzhou 311200, China)

机构地区：[1]杭州市萧山区第一人民医院肛肠外科,浙江杭州311200

出　　处：《中国生化药物杂志》2017年第12期152-154,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探究透皮给药靶向治疗对肛瘘术后创面愈合及肛门疼痛的影响。方法选取2013年1月～2015年1月杭州市萧山区第一人民医院收治的肛瘘切除术患者138例，采用随机字母表法分为观察组与对照组，每组69例。对照组患者术后给予无菌敷料外敷，塔形纱布固定，观察组患者术后进行透皮给药靶向治疗，对比2组患者临床疗效、愈合时间、愈合率、肛门疼痛积分及肛门肿胀评分。结果观察组患者总有效率98.55％显著高于对照组88.41％（P＜0.05）；观察组患者创面愈合时间明显短于对照组（P＜0.05），术后7d及14d创面愈合率均显著高于对照组（P＜0.05）；观察组患者术后2d肛门VAS积分与对照组相比差异无统计学意义，术后7d及14d肛门VAS积分均明显低于对照组（P＜0.05）；观察组患者术后2d、7d及14d肿胀积分均明显低于对照组（P＜0.05）。结论透皮给药靶向治疗可促进肛瘘术后创面愈合，提高临床疗效，减轻肛门疼痛与肿胀。Objective To explore the influence of transdermal drug delivery targeted therapy on wound healing and anal pain after anal fistula surgery.Methods138patients with anal fistula resection were enrolled in our hospital from January2013to January2015.The patients were divided into observation group and control group by random alphabet,with69cases in each group.The patients in the control group were treated with sterile dressing,the patients in the observation group were treated with transdermal drug delivery,and the clinical efficacy,healing time,healing rate,anal pain score and anal swelling score were compared between the two groups.Results The total effective rate of the observation group was98.55%,significantly higher than88.41%of the control group(P<0.05).The wound healing time of the observation group was significantly shorter than that of the control group(P<0.05),and the healing rate of7d and14d after operation was significantly higher than that of the control group(P<0.05).There was no significant difference in VAS score between the two groups.The VAS score of the anus was significantly lower than that of the control group at7days and14days after operation(P<0.05).The swelling scores of2d,7d and14d in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Transdermal drug delivery targeted therapy can promote wound healing after anal fistula operation,and improve clinical effect and reduce pain and anus swelling.

关 键 词：透皮给药 靶向治疗 肛瘘术 创面愈合 肛门疼痛 

分 类 号：R657.16[医药卫生—外科学]