原花青素对中度持续哮喘患者血清中IL-4的影响研究  

Effect of proanthocyanidins on IL-4in moderate persistent asthma patients

作　　者：史莹[1] 周丹阳 谷伟[1] SHI Ying;ZHOU Dan-yang;GU Wei(Department of Respiratory Medicine, the First Hospital of Nanjing, Nanjing 210006, China)

机构地区：[1]南京市第一医院呼吸科,江苏南京210006

出　　处：《中国生化药物杂志》2017年第12期345-346,共2页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的研究原花青素对中度持续哮喘患者血清中白细胞介素-4（IL-4）的影响。方法对中度持续状态的哮喘患者进行原花青素的干预，为期1周。在干预前及干预后分别取患者静脉血，分离血清后，检测血清中IL-4的含量。结果中度持续状态的哮喘患者治疗前血清中IL-4为（17.25±1.86）ng/L，原花青素干预后患者血清IL-4为（14.08±1.31）ng/L。治疗前后对比，差异具有统计学意义（P＜0.05）。结论原花青素能明显降低中度持续哮喘患者血中IL-4，可能对抑制哮喘患者气道炎症起重要作用。Objective To investigate the effect of proanthocyanidins on IL-4expression of asthma patients.Methods Moderate persistent asthma patients received proanthocyanidins treatment for1week.Before and after the proanthocyanidins treatment,patients were taken the venous blood.After centrifugation and separation of serum,we detected the content of IL-4.Results The IL-4level in patients was(17.25±1.86)ng/L.After proanthocyanidins treatment,the IL-4level in patients was(14.08±1.31)ng/L.Conclusion Proanthocyanidins can reduce IL-4level of asthma patients.Maybe the reduced IL-4contributes to inhibit the airway inflammation in asthma.

关 键 词：哮喘 白细胞介素-4 原花青素 

分 类 号：R562.25[医药卫生—呼吸系统]