化疗药物对心脏毒副作用的心电图表现与病理分析  

Electrocardiographic manifestations and pathological analysis of chemotherapy drugs on cardiac toxicity

作　　者：林波 程震锋[2] LIN Bo;CHENG Zhen-feng(Electrocardiogram Room, Huzhou Central Hospital, Huzhou 313000, China;Department of Cardidogy, Huzhou Central Hospital, Huzhou 313000, China)

机构地区：[1]湖州市中心医院心电图室,浙江湖州313000 [2]湖州市中心医院心内科,浙江湖州313000

出　　处：《中国生化药物杂志》2017年第12期400-401,共2页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探究化疗药物对心脏毒副作用的心电图表现与病理概况。方法选取湖州市中心医院2015年1月～2017年2月接受化疗治疗的40例妇科肿瘤患者作为观察组；选择同期采用分泌疗法治疗的40例妇科肿瘤患者作为对照组；分析化疗对患者产生心脏毒副作用的心电图表现，同时探究其病理情况。结果化疗药物对心脏毒副作用的心电图表现为：室上性心动过速、偶有束支传导阻滞、ST-T段的非特异性改变、QRS低电压、QT间期延长、室性期前收缩等情况。对照组无心电图异常表现。结论化疗药物虽然能够产生一定治疗效果，但是会导致患者心电图异常表现，因此临床应该注重对患者实施联合治疗措施，或者控制药物用量，或者给予早期毒副作用的干预和预防，减少毒副作用对患者产生的影响。Objective To explore the toxicity of chemotherapy drugs on ECG cardiac manifestations and pathological situation.Methods40cases of gynecologic cancer patients treated by chemotherapy in Huzhou Central Hospital from January2015to February2017were selected as observation group,and40cases of gynecologic tumor patients treated with secretory therapy were selected as control group.The ECG manifestations of cardiac toxic side effects of chemotherapy were analyzed,and the pathological condition was also explored.Results The electrocardiogram of chemotherapy drugs on cardiac toxicity for supraventricular tachycardia,with bundle branch block,nonspecific ST-T segment changes,QRS low voltage,QT prolongation,ventricular contractions and so on.The control group had no ECG abnormalities.Conclusion Although chemotherapy can produce a certain therapeutic effect,but can lead to patients with abnormal ECG findings,the clinical should pay attention to the combined treatment measures for patients,or drug control dosage,or give early intervention and prevention of toxic and side effects,reduce the toxic side effects on patients.

关 键 词：化疗药物 心脏毒副作用 心电图表现 病理 

分 类 号：R469.3[医药卫生—临床医学]