不同分期糖尿病视网膜病变患者外周血中AT-Ⅲ、PAI、t-PA变化的研究  

Research on AT-Ⅲ,PAI and t-PA in patients with different stages of diabetic retinopathy

作　　者：姜璐璐 于春霞[1] 热娜古丽.艾则孜 穆塔里甫[1] Lu-Lu Jiang;Chun-Xia Yu;Reina Gurui;Mutallipo(Department of Ophtalmology,First Affiliated Hospital of Xinjiang Medical University,Urumchi 830000, Xinjiang Uygur Autonomous Region,China)

机构地区：[1]新疆医科大学第一附属医院眼科

出　　处：《国际眼科杂志》2018年第1期140-142,共3页International Eye Science

基　　金：国家自然科学基金项目(No.81360149)~~

摘　　要：目的:寻找糖尿病视网膜病变不同分期与血管内皮功能的相关因子之间的内在联系,从改善血管内皮功能方面为寻找延缓甚至抑制DR的发生或进展的方法提供理论依据。方法:收集2015-03/12在本院眼科及内分泌科住院的2型糖尿病患者178例及健康对照组62例的血样标本;根据眼底血管荧光造影(FFA)结果糖尿病组患者可分为无视网膜病变组、非增殖性视网膜病变组、增殖性视网膜病变组;检测血样标本中抗凝血酶Ⅲ(AT-Ⅲ)、纤溶酶原激活抑制物(PAI)、组织型纤溶酶原激活剂(t-PA)指标与糖尿病视网膜病变分期的相关性。结果:本研究表明无糖尿病视网膜病变组、非增殖期糖尿病视网膜病变组、增殖期糖尿病视网膜病变组及对照组AT-Ⅲ比较,差异具有统计学意义(F=5.986,P<0.01);无糖尿病视网膜病变组、非增殖期糖尿病视网膜病变组、增殖期糖尿病视网膜病变组、对照组PAI比较,差异具有统计学意义(F=7.434,P<0.01);无糖尿病视网膜病变组、非增殖期糖尿病视网膜病变组、增殖期糖尿病视网膜病变组及对照组t-PA比较,差异无统计学意义(F=2.556,P>0.05)。糖尿病视网膜病变的程度与AT-Ⅲ、PAI的含量有着密切的关系。结论:糖尿病视网膜病变发生程度与抗凝血酶Ⅲ、纤溶酶原激活抑制物的含量有着密切的关系。AIM:To explore the relationship between the different stages of diabetic retinopathy and the related factors of vascular endothelial function,and to provide a theoretical basis for improving the function of vascular endothelium to find a way to delay or even inhibit the occurrence or progression of DR.METHODS:We collected during March2015to December2015in Department of Ophthalmology and endocrinology in our hospital,178cases of type2diabetes mellitus patients and62cases of blood specimen in health control group.According to the results of fundus fluorescence angiography(FFA),they were divided into four groups,diabetes patients without retinopathy,diabetes patients with non-proliferative diabetic retinopathy(NPDR),diabetes patients with proliferative diabetic retinopathy(PDR)and healthy control group.We detected blood samples of antithrombin III(AT-III),fibrinolytic enzyme activation inhibitor(PAI),the original organization type fibrinolytic enzyme activator(t-PA)index and the correlation of diabetic retinopathy in installment.RESULTS:This study showed that AT-III was significantly different among the four groups(F=5.986,P<0.01);PAI was significantly different among the patients without DR,patients with NPDR and patients with PDR(F=7.434,P<0.01);t-PA was not significantly different among the four groups(F=2.556,P>0.05);there were relations between the different stages of diabetic retinopathy and AT-III,PAI.CONCLUSION:The degree of diabetic retinopathy has a close relationship with the content of antithrombin III and plasminogen activator inhibitor,and it is closely related to the function of vascular endothelium.

关 键 词：糖尿病视网膜病变 血管内皮因子 糖尿病视网膜病变分期 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]