难治性肺炎支原体肺炎患儿血浆D-二聚体与血清IL-6水平变化及临床意义  

The level changes of plasma D-dimer and serum interleukin-6 in children with refractory pneumonia mycoplasma pneumonia,as well their relationship with the disease

作　　者：董九伟[1] 姜晓华[1] 孙玉晶 朱文灵 张伟强 王玲玲 姜娅男 任杰 刘颖 DONG Jiu-wei;JIANG Xiao-hua;SUN Yu-jing(No. 107 Hospital of PLA,Yantai,Shandong 264002,China)

机构地区：[1]解放军107医院,山东烟台264002

出　　处：《实用医药杂志》2017年第11期1000-1003,共4页Practical Journal of Medicine & Pharmacy

摘　　要：目的探讨血浆D-二聚体与血清IL-6水平在难治性肺炎支原体肺炎(refractory mycoplasma pneumoniae pneumonia,RMPP)中的临床意义。方法选取2015年2月—2016年12月在解放军第107医院儿科病房被诊断为肺炎支原体肺炎(mycoplasma pneumoniae pneumonia,MPP)患者,依据患者年龄、临床症状及影像学特点,分为RMPP组、普通MPP组(general mycoplasma pneumoniae pneumonia,GMPP)。其中RMPP组22例,男12例,女10例;年龄(6.31±2.52)岁。GMPP组24例,男10例,女14例;年龄(6.48±2.29)岁。选择同期该院儿保门诊健康查体的健康儿童20名作为(健康)对照组,其中,男9例,女11例;年龄(6.18±2.69)岁。对RMPP组、GMPP组患者于治疗前以及同期对照组儿童进行血浆D-二聚体与血清IL-6水平的检测,并进行统计学分析。结果 RMPP组于治疗前D-二聚体、IL-6水平明显高于GMPP组、对照组,差异有统计学意义(P<0.05),二者呈显著正相关(r=0.6102,P=0.001)。结论及时动态监测D-二聚体与IL-6水平对于早期及时评估患者病情严重程度、指导治疗及评价预后有重要临床意义。Objective To investigate the clinical significance of plasma D-dimer and serum IL-6in refractory mycoplasma pneumoniae pneumonia(RMPP).Methods According to the age,clinical symptoms and imaging characteristics of children with mycoplasma pneumoniae(MPP)in the pediatric ward of No.107hospital from Feb.2015to Dec.2016yr,who were divided into RMPP group,GMPP group.There were22cases in RMPP group,12cases of male and10cases of female,age(6.31±2.52)years old;GMPP group of24cases,male10cases,female14cases,age(6.48±2.29)years old.Twenty healthy children were selected as healthy(healthy)control group,including9males and11females,aged(6.18±2.69)years old.The levels of plasma D-dimer and serum IL-6were detected in RMPP group and GMPP group before and after treatment(recovery period)and the control group,and the statistical analysis was carried out.Results The levels of D-dimer and IL-6in RMPP group were significantly higher than those in GMPP group and control group(P<0.05),and there was significant positive correlation between them(r=0.6102,P=0.001).Conclusion Monitoring D-dimer and IL-6levels has important clinical implications for early and timely assessment of the severity of the disease,for guiding treatment and evaluating the prognosis.

关 键 词：难治性肺炎支原体肺炎 血浆D-二聚体 血清IL-6 相关性 

分 类 号：R725.5[医药卫生—儿科]