左卡尼汀+辅酶Q10辅助治疗对慢性心力衰竭患者血管活性分子、内皮损伤、氧化应激反应的影响  

Effect of levocarnitine + coenzyme Q10 adjuvant therapy on vasoactive molecules,endothelial injury and oxidative stress in patients with chronic heart failure

作　　者：李勤[1] 刘盈盈[2] LI Qin;LIU Ying ying(Department of Cardiovascular Medicine, the First People’s Hospital of Yibin City in Sichuan Province, Yibin City, Sichuan Province, 644000, China;Electrocardiogram Room, the First People’s Hospital of Yibin City in Sichuan Province, Yibin City, Sichuan Province, 644000, China)

机构地区：[1]四川省宜宾市第一人民医院心血管内科,四川宜宾644000 [2]四川省宜宾市第一人民医院心电图室,四川宜宾644000

出　　处：《海南医学院学报》2017年第18期2472-2475,共4页Journal of Hainan Medical University

基　　金：四川省医学会课题项目(Q15035)~~

摘　　要：目的:探讨左卡尼汀+辅酶Q10辅助治疗对慢性心力衰竭患者血管活性分子、内皮损伤、氧化应激反应的影响。方法:收集在本院接受治疗的慢性心力衰竭患者90例,随机分为对照组及观察组,每组各45例。对照组接受常规治疗,观察组在常规治疗基础上加入左卡尼汀+辅酶Q10辅助治疗。对比两组治疗前后血管活性分子、内皮损伤、氧化应激水平的差异。结果:治疗前,两组血管活性分子、内皮损伤、氧化应激水平的差异无统计学意义。治疗后,观察组血清中血管活性分子ET-1、AngⅡ、TXB2的含量低于对照组,NO的含量高于对照组;内皮功能指标FMD的水平高于对照组;血清中氧化应激指标SOD、T-AOC的含量高于对照组,MDA、ROS的含量低于对照组。结论:左卡尼汀+辅酶Q10辅助治疗可优化慢性心力衰竭患者的血管活性,降低内皮损伤及全身氧化应激反应。Objective:To study the effect of levocarnitine+coenzyme Q10adjuvant therapy on vasoactive molecules,endothelial injury and oxidative stress in patients with chronic heart failure.Methods:90patients with chronic heart failure who were treated in the hospital between December2014and December2016were collected and divided into control group and observation group by random number table method,45cases in each group.Control group received conventional therapy,and observation group received levocarnitine+coenzyme Q10adjuvant therapy on the basis of conventional therapy.The differences in vasoactive molecule,endothelial injury and oxidative stress levels were compared between the two groups before and after treatment.Results:Before treatment,the differences in vasoactive molecule,endothelial injury and oxidative stress levels were not statistically significant between the two groups of patients.After treatment,serum vasoactive molecules ET1,AngⅡand TXB2contents of observation group were lower than those of control group while NO content was higher than that of control group;endothelial function indexes FMD level was higher than that of control group;serum oxidative stress indexes SOD and T AOC contents were higher than those of control group while MDA and ROS contents were lower than those of control group.Conclusion:Levocarnitine+coenzyme Q10adjuvant therapy can optimize the vascular activity,and reduce the endothelial injury and systemic oxidative stress response in patients with chronic heart failure.

关 键 词：慢性心力衰竭 左卡尼汀 辅酶Q10 内皮损伤 氧化应激 

分 类 号：R541.6[医药卫生—心血管疾病]